The effect of interactions between BMI and sustained depressive symptoms on knee osteoarthritis over 4 years: data from the osteoarthritis initiative

Table 2 Interactions between BMI (normal/obese) and sustained depression over 4 years (yes/no) and outcomes (WOMAC pain, JSN, cartilage T₂). An additional interaction between BMI-sustained depression-sex was included to test for sex differences. If significant, the analysis was subdivided by sex. All mixed effects models were adjusted for age, sex, BMI, and race

	WOMAC Pain	JSN	Cartilage T₂
P value for the interaction between BMI and sustained depression	< 0.001	0.08	0.27
P value for the interaction between BMI and sustained depression in participants with KL 0/1 in both knees at baseline	< 0.001	0.02	0.25
P value for the interaction between BMI and sustained depression and sex (male/female)	0.02	0.03	0.39
P value for the interaction between BMI and sustained depression) in males	0.33	0.35	*
P value for the interaction between BMI and sustained depression in females	< 0.001	0.01	*

* Note analysis this analysis was not subdivided by males/females since the interaction BMI and sustained depression and sex was not significant

ISSN: 1471-2474