Table 1 Participant characteristics at the baseline timepoint. Abbreviations: KL: Kellgren Lawrence, PASE: physical activity scale for the elderly; CES-D: the Center for Epidemiological Studies Depression; JSNmax: maximum joint space narrowing score. Note: cartilage T2 sequences were only acquired in the right knee in the OAI
No Depression & Normal BMI (N = 772) | Depression & Normal BMI (N = 33) | No Depression & Obese (N = 971) | Depression & Obese (N = 68) | Total (N = 1844) | P-value | |
|---|---|---|---|---|---|---|
Age (years) | 0.00211 | |||||
Mean (SD) | 61.2 (9.29) | 58.9 (8.64) | 60.1 (8.49) | 57.5 (8.30) | 60.4 (8.86) | |
BMI (kg/m2) | < 0.00011 | |||||
Mean (SD) | 22.8 (1.55) | 22.0 (2.19) | 33.4 (2.96) | 35.0 (3.58) | 28.8 (5.90) | |
Sex, n (%) | < 0.00012 | |||||
Male | 232 (30.1%) | 8 (24.2%) | 399 (41.1%) | 16 (23.5%) | 655 (35.5%) | |
Female | 540 (69.9%) | 25 (75.8%) | 572 (58.9%) | 52 (76.5%) | 1189 (64.5%) | |
CES-D scale | < 0.00011 | |||||
Mean (SD) | 4.0 (3.70) | 24.9 (9.25) | 4.7 (3.94) | 23.9 (7.86) | 5.5 (6.18) | |
WOMAC pain right | < 0.00011 | |||||
Mean (SD) | 1.3 (2.05) | 1.9 (3.27) | 2.3 (2.91) | 5.4 (4.61) | 2.0 (2.81) | |
WOMAC pain left | < 0.00011 | |||||
Mean (SD) | 1.2 (2.29) | 1.9 (3.05) | 2.2 (3.20) | 5.9 (5.13) | 1.9 (3.09) | |
Race, n (%) | < 0.00012 | |||||
0 – Other-non-white | 4 (0.5%) | 0 (0.0%) | 14 (1.4%) | 1 (1.5%) | 19 (1.0%) | |
1 – White or Caucasian | 710 (92.1%) | 27 (81.8%) | 724 (74.6%) | 42 (61.8%) | 1503 (81.6%) | |
2 – Black or African American | 41 (5.3%) | 5 (15.2%) | 230 (23.7%) | 25 (36.8%) | 301 (16.3%) | |
3 - Asian | 16 (2.1%) | 1 (3.0%) | 3 (0.3%) | 0 (0.0%) | 20 (1.1%) | |
Missing | 1 | 0 | 0 | 0 | 1 | |
KL grade right, n (%) | < 0.00012 | |||||
0 | 429 (55.6%) | 18 (54.5%) | 282 (29.0%) | 14 (20.6%) | 743 (40.3%) | |
1 | 137 (17.7%) | 3 (9.1%) | 183 (18.8%) | 13 (19.1%) | 336 (18.2%) | |
2 | 146 (18.9%) | 9 (27.3%) | 335 (34.5%) | 26 (38.2%) | 516 (28.0%) | |
3 | 60 (7.8%) | 3 (9.1%) | 171 (17.6%) | 15 (22.1%) | 249 (13.5%) | |
KL grade left, n (%) | < 0.00012 | |||||
0 | 445 (57.6%) | 20 (60.6%) | 307 (31.6%) | 15 (22.1%) | 787 (42.7%) | |
1 | 135 (17.5%) | 3 (9.1%) | 187 (19.3%) | 9 (13.2%) | 334 (18.1%) | |
2 | 137 (17.7%) | 7 (21.2%) | 320 (33.0%) | 28 (41.2%) | 492 (26.7%) | |
3 | 55 (7.1%) | 3 (9.1%) | 157 (16.2%) | 16 (23.5%) | 231 (12.5%) | |
PASE | 0.00991 | |||||
Mean (SD) | 169.0 (77.46) | 142.0 (83.50) | 160.7 (85.64) | 156.3 (91.98) | 163.7 (82.63) | |
Mean cartilage T2 right (ms) | 0.00031 | |||||
Mean (SD) | 33.1 (1.95) | 33.3 (2.39) | 33.3 (1.98) | 34.0 (2.17) | 33.3 (1.99 | |
JSNmax right | < 0.0011 | |||||
Mean (SD) | 0.4 (0.62) | 0.3 (0.65) | 0.7 (0.76) | 0.9 (0.76) | 0.5 (0.72) | |
JSNmax left | < 0.0011 | |||||
Mean (SD) | 0.3 (0.60) | 0.3 (0.65) | 0.6 (0.75) | 0.8 (0.80) | 0.5 (0.71) |