Table 1 Quality Appraisal tool

1. Was the research question or objective in this paper clearly stated?

2. Was the study population specified and defined?

3. Was there a justification for the instrument used?

4. Was the design appropriate to meet the aims?

5. Was the specifications of the subject group adequately given?

6. Was a sample size justification, power description, or variance and effect estimates provided?

7. Was the statistical methods adequately described?

8. Was the data adequately described?

9. Assessment of statistical significance

10. Attention to potential biases

11. Was the exposure assessed more than once over time?

12. Comparison of results with previous reports

13. Was there any implications in real life?