Fig. 8

Schematic representation of the action of treadmill training on the bone in aged rats. Treadmill training alters the inflammatory bone microenvironment by inhibiting NLPRP3/Caspase1/IL-1β signaling in bone marrow (1) and downregulating serum TNF-α and IL-1β (2), which in turn improves the bone mass and bone microarchitecture by increasing bone formation and decreasing bone resorption