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Table 4 Correlations between baseline biomarker levels and 4- week change in pain/disability scores

From: The association of biomarkers with pain and function in acute and subacute low back pain: a secondary analysis of an RCT

Biomarker

Treatment

Change in pain

Change in ODI

r

p

r

p

NPY

Group 1

−.15

.430

−.13

.480

Group 2

.19

.347

−.03

.857

Group 3

−.29

.129

−.24

.202

E-Selectin

Group 1

.04

.834

−.00

.978

Group 2

.10

.615

.38

.056

Group 3

.07

.711

.08

.674

TNFα

Group 1

.16

.396

.28

.124

Group 2

−.15

.449

.13

.516

Group 3

.06

.741

−.18

.357

SubP

Group 1

−.00

.982

−.14

.436

Group 2

.10

.612

.33

.095

Group 3

.13

.494

.28

.186

RANTES

Group 1

.24

.197

−.04

.846

Group 2

−.16

.434

−.01

.946

Group 3

−.05

.783

−.26

.186

Vitamin D

Group 1

.24

.204

.33

.070

Group 2

−.05

.812

−.24

.231

Group 3

−.15

.443

−.02

.923

CRP

Group 1

−.26

.165

−.24

.199

Group 2

.20

.311

.31

.111

Group 3

.26

.179

.06

.748

  1. Group 1 (n = 33) = manual manipulation Group 2 (n = 27) = mechanical manipulation Group 3 (n = 30 for pain; n = 29 for ODI) = medical care
  2. NPY Neuropeptide Y, TNFα Tumor necrosis factor-alpha, SubP Substance P, RANTES Regulated upon activation, normal t-cell expressed and presumably secreted; D, CRP c-reactive protein, r Spearman’s correlation coefficient, ODI Oswestry Disability Index