Fig. 5
Reduced fracture resilience of old Nrf2-specific KO femurs
Peak force [Forcemax (N)] (a) and stiffness (N/mm) (b) of femurs from female young adult and old WT mice were compared to Nrf2-specific KO specimens using the Wilcoxon rank sum test. The correlation of forcemax (N) (c) and stiffness (N/mm) (d) with cortical bone fraction [Ct.Ar/Tt.Ar (%)] from μCT data was evaluated using the Spearman’s Rank correlation coefficient. Representative full-field strain maps (main principal true strains) of 4 groups of the murine femurs at the failure point by using a Digital Image Correlation (DIC) system. The DIC images are taken at the maximum force values of each specimen (i.e., 150 N, 94.54 N, 41.05 N, and 56.47 N for each specimen from left to right) (e). Values are expressed as means ± SEM. *p < 0.05 indicates significance