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Fig. 3 | BMC Musculoskeletal Disorders

Fig. 3

From: Nuclear factor erythroid 2–related factor 2 (Nrf2) deficiency causes age-dependent progression of female osteoporosis

Fig. 3

Trabecular and cortical parameters calculated for different bone groups

Comparison trabecular (Tb) bone parameters in femoral neck (a) and metaphysis (b) including Tb. Th (μm), BMD (IU), bone surface (mm2), and BV/TV (%) between young adult and old WT and Nrf2- specific KO mice. Comparison of cortical bone parameters of femoral neck (c) and diaphysis (d) section including Ct. Th (μm), Tt. Ar (mm2), Ct. Ar (mm2), and Ct.Ar/Tt.Ar (%) between WT and KO mice in young mature and old animals. Wilcoxon rank sum test was used for statistics. Values are means ± SEM. Tb. Th, trabecular thickness; BMD, bone mineral density; BS, bone surface; BV/TV, bone volume fraction; Ct. Th, cortical thickness; Tt. Ar, total cross-sectional area inside the periosteal envelope; Ct. Ar, cortical bone area; Ct.Ar/Tt.Ar, cortical bone fraction; *ρ < 0.05 and **ρ < 0.001 indicate significance; ns, not significant; SEM, standard error of the mean

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