Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort

Table 5 Baseline cartilage damage (full thickness score)

N = 286			All knees		No ROA		ROA		P-value
N = 286			Frequency	Percent	Frequency	Percent	Frequency	Percent
Knee	Max score	0	71	24.8	61	47.3	10	6.4	0.0000
		1	47	16.4	27	20.9	20	12.7
		2	118	41.3	39	30.2	79	50.3
		3	50	17.5	2	1.6	48	30.6
	Number of regions	0	71	24.8	61	47.3	10	6.4	0.0000
		1	51	17.8	31	24.0	20	12.7
		2	43	15.0	23	17.8	20	12.7
		3	43	15.0	8	6.2	35	22.3
		4	31	10.8	6	4.7	25	15.9
		5	22	7.7	0	0.0	22	14.0
		6 +	25	8.7	0	0.0	25	15.9
MFTJ	Max score	0	186	65.0	114	88.4	72	45.9	0.0000
		1	34	11.9	9	7.0	25	15.9
		2	49	17.1	6	4.7	43	27.4
		3	17	5.9	0	0.0	17	10.8
	Number of regions	0	186	65.0	114	88.4	72	45.9	0.0000
		1	50	17.5	13	10.1	37	23.6
		2	17	5.9	1	0.8	16	10.2
		3	14	4.9	1	0.8	13	8.3
		4 +	19	6.6	0	0.0	19	12.1
LFTJ	Max score	0	200	69.9	110	85.3	90	57.3	0.0000
		1	35	12.2	12	9.3	23	14.6
		2	41	14.3	7	5.4	34	21.7
		3	10	3.5	0	0.0	10	6.4
	Number of regions	0	200	69.9	110	85.3	90	57.3	0.0000
		1	42	14.7	16	12.4	26	16.6
		2	14	4.9	3	2.3	11	7.0
		3	12	4.2	0	0.0	12	7.6
		4 +	18	6.3	0	0.0	18	11.5
PFJ	Max score	0	122	42.7	73	56.6	49	31.2	0.0000
		1	58	20.3	26	20.2	32	20.4
		2	81	28.3	28	21.7	53	33.8
		3	25	8.7	2	1.6	23	14.6
	Number of regions	0	122	42.7	73	56.6	49	31.2	0.0000
		1	71	24.8	34	26.4	37	23.6
		2	62	21.7	16	12.4	46	29.3
		3	23	8.0	5	3.9	18	11.5
		4	8	2.8	1	0.8	7	4.5

ISSN: 1471-2474