Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort

Roemer, Frank W.; Jansen, Mylène; Marijnissen, Anne C. A.; Guermazi, Ali; Heiss, Rafael; Maschek, Susanne; Lalande, Agnes; Blanco, Francisco J.; Berenbaum, Francis; van de Stadt, Lotte A.; Kloppenburg, Margreet; Haugen, Ida K.; Ladel, Christoph H.; Bacardit, Jaume; Wisser, Anna; Eckstein, Felix; Lafeber, Floris P. J. G.; Weinans, Harrie H.; Wirth, Wolfgang

doi:10.1186/s12891-022-05926-1

Table 2 Intra- and Inter-reader Reliability APPROACH MOAKS Assessment (Baseline)

From: Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort

N = 2		Intra-observer				Inter-observer
N = 2		Weighted Kappa	Std. Error	95% CI		Weighted Kappa	Std. Error	95% CI
Maximum cartilage score	MFTJ	0.79	0.08	0.62	0.95	0.89	0.05	0.79	0.98
	LFTJ	0.95	0.03	0.89	1.01	0.96	0.02	0.91	1.01
	PFJ	0.88	0.07	0.75	1.02	0.76	0.09	0.57	0.94
	Knee	0.75	0.09	0.58	0.92	0.85	0.06	0.73	0.97
Maximum cartilage area score	MFTJ	0.88	0.07	0.74	1.01	0.82	0.10	0.62	1.02
	LFTJ	1.00	0.00	1.00	1.00	0.96	0.04	0.89	1.04
	PFJ	0.87	0.09	0.70	1.04	0.72	0.15	0.43	1.02
	Knee	0.71	0.14	0.43	0.98	0.76	0.12	0.52	0.99
Maximum cartilage full thickness score	MFTJ	0.81	0.08	0.66	0.96	0.82	0.10	0.62	1.02
	LFTJ	0.90	0.07	0.77	1.03	0.90	0.06	0.78	1.02
	PFJ	1.00	0.00	1.00	1.00	0.88	0.08	0.72	1.04
	Knee	0.88	0.07	0.75	1.01	0.88	0.07	0.75	1.01
Number of cartilage subregions with score > 0	MFTJ	0.95	0.03	0.89	1.02	0.95	0.03	0.89	1.02
	LFTJ	1.00	0.00	1.00	1.00	0.97	0.03	0.91	1.03
	PFJ	0.84	0.08	0.69	0.99	0.92	0.06	0.81	1.03
	Knee	0.92	0.03	0.85	0.98	0.94	0.03	0.88	0.99
Maximum BML size score	MFTJ	0.94	0.06	0.82	1.06	1.00	0.00	1.00	1.00
	LFTJ	1.00	0.00	1.00	1.00	1.00	0.00	1.00	1.00
	PFJ	1.00	0.00	1.00	1.00	0.91	0.09	0.74	1.08
	Knee	0.95	0.05	0.86	1.04	1.00	0.00	1.00	1.00
Number of regions with BML score > 0	MFTJ	0.97	0.03	0.91	1.03	0.97	0.03	0.91	1.03
	LFTJ	1.00	0.00	1.00	1.00	0.89	0.06	0.77	1.01
	PFJ	1.00	0.00	1.00	1.00	0.86	0.10	0.67	1.04
	Knee	0.98	0.02	0.93	1.02	0.88	0.05	0.79	0.97
Maximum osteophyte score	MFTJ	0.95	0.05	0.86	1.04	0.77	0.10	0.57	0.96
	LFTJ	0.84	0.07	0.71	0.98	0.74	0.09	0.58	0.91
	PFJ	0.84	0.08	0.69	1.00	0.80	0.10	0.60	0.99
	Knee	0.91	0.06	0.79	1.03	0.91	0.06	0.79	1.03
Meniscus morphology score (range 0–8)	MFTJ	0.93	0.07	0.80	1.06	0.90	0.06	0.79	1.01
Meniscus morphology score (range 0–8)	LFTJ	0.93	0.05	0.83	1.03	0.83	0.06	0.71	0.95
Meniscus morphology score (range 0:no/signal,1:tear,2:maceration)	MFTJ	0.95	0.05	0.84	1.05	0.89	0.07	0.75	1.03
	LFTJ	1.00	0.00	1.00	1.00	0.94	0.06	0.83	1.05
Meniscus extrusion (range 0–3)	MFTJ	0.96	0.04	0.88	1.04	0.92	0.06	0.81	1.03
Meniscus extrusion (range 0–3)	LFTJ	0.88	0.08	0.72	1.03	0.94	0.07	0.81	1.07
Meniscus extrusion (0/1 vs 2/3)	MFTJ	1.00	0.00	1.00	1.00	0.90	0.10	0.71	1.09
Meniscus extrusion (0/1 vs 2/3)	LFTJ	1.00	0.00	1.00	1.00	1.00	0.00	1.00	1.00
Hoffa synovitis	Knee	0.85	0.10	0.65	1.05	0.87	0.09	0.69	1.04
Effusion synovitis	Knee	1.00	0.00	1.00	1.00	0.89	0.08	0.74	1.04

MFTJ Medial tibio-femoral joint, LFTJ lateral tibio-femoral joint, PFJ Patellofemoral joint, Std Standard

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