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Table 2 Associations with radiographic knee osteoarthritis(RKOA, Ahlbäck grade I or more in at least one knee) analysed with two logistic regression models. One univariate and one adjusting for age and sex

From: Associations between metabolic factors and radiographic knee osteoarthritis in early disease - a cross-sectional study of individuals with knee pain

 

Univariate logistic regression

Adjusting for age and sex

 

OR

95% CI

p-value

OR

95% CI

p-value

Age, years

1.13

1.07,1.19

< 0.001

1.13

1.07, 1.19

< 0.001

Sex, women

0.93

0.51,1.70

0.81

   

BMI

1.08

1.02,1.14

0.013

1.06

1.00,1.13

0.06

BMI ≥ 25, kg/m2

2.02

1.12,3.65

0.020

1.87

0.99,3.52

0.05

Visceral fat area (VFA), cm2

1.01

1.00,1.01

0.016

1.01

1.00,1.01

0.08

Raised VFA (≥ 100), cm2

2.46

1.36,4.47

0.003

2.43

1.29,4.55

0.006

Proportion of fat, %

1.03

1.00,1.07

0.044

1.03

0.99,1.07

0.11

Waist circumferance, cm

1.03

1.00,1.05

0.012

1.02

1.00,1.05

0.06

Central obesity*

6.08

1.83,20.22

0.003

5.19

1.52,17.72

0.009**

Raised blood pressure*

0.74

0.42,1.31

0.31

   

CRP, mg/L

1.05

0.95,1.16

0.34

   

Total cholesterol, mmol/L

1.29

1.00,1.66

0.055

1.08

0.81,1.43

0.61***

Triglycerides, mmol/L

1.40

0.92,2.14

0.12

1.19

0.75, 1.90

0.46***

Raised triglycerides*

2.21

1.02,4.78

0.045

1.92

0.84,4.36

0.12

LDL-cholesterol, mmol/L

1.31

1.00,1.71

0.048

1.12

0.84,1.50

0.45***

Reduced HDL-cholesterol*

1.18

0.52,2.66

0.69

   

Glucose, mmol/L

0.99

0.70,1.40

0.97

   

Raised glucose*

0.94

0.52,1.70

0.84

   

HBA1c, mmol/mol

1.01

0.95,1.07

0.77

   

MetS*

1.49

0.81,2.74

0.20

   
  1. BMI, body mass index; CRP, C-reactive protein; LDL, low density lipoprotein; HDL, high density lipoprotein; HbA1C, glycosylated hemoglobin; MetS, metabolic syndrome
  2. *according to International Diabetes Federation (IDF) **controlled only for age *** Triglycerides, cholesterol and LDL-cholesterol were also controlled for lipid-lowering treatment