A2A adenosine receptor agonist reduced MMP8 expression in healthy M2-like macrophages but not in macrophages from ankylosing spondylitis patients

Table 4 The mRNA expression of BMP2, MMP8, and MMP9 in monocyte-derived (M2-like) macrophages from AS patients and healthy controls before and after CGS-21,680 treatment

	Relative gene expression
	Healthy macrophages	Treated healthy macrophages	Mean fold changes (95% CI)	P -value
*BMP2*	0.19 ± 0.07	0.19 ± 0.10	0.99 (0.77, 1.26)	0.974
*MMP8*	0.11 ± 0.09	0.03 ± 0.01	0.26 (0.19, 0.36)	0.002
*MMP9*	4333.5 ± 2247.9	5556.2 ± 3580.8	1.28 (0.98, 1.68)	0.101
	AS macrophages	Treated AS macrophages	Mean fold changes (95% CI)	P -value
*BMP2*	0.09 ± 0.05	0.15 ± 0.11	1.62 (0.96, 2.72)	0.167
*MMP8*	0.07 ± 0.09	0.05 ± 0.08	0.78 (0.45, 1.34)	0.122
*MMP9*	4860.4 ± 1943.2	4696.05 ± 1372.1	0.97 (0.84, 1.11)	0.729

ISSN: 1471-2474