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Table 1 Study characteristics and design

From: Diagnostic accuracy of the Ottawa ankle rule to exclude fractures in acute ankle injuries in adults: a systematic review and meta-analysis

Study

Year

Region

Study design

Sample size

Age (mean ± STDEV)

Sampling method

Reference standard (Radiography and/or follow up)

Radiograph interpretation (radiologist or ED physician)

Follow-up interpretation

Auley 1998 [1]

1998

France

Prospective validation survey

416

34 [range: 18–90]

Consecutive

Radiography

ED physician at time of visit + blinded radiologist (for OAR performance)

No follow up

Beceren 2013 [3]

2013

Turkey

Randomized prospective

962

30.3 ± 13.2

Consecutive

Radiography

Orthopaedic surgery resident

N/R

Broomhead 2003 [5]

2003

Australia

Prospective validation study

333

34.7 [range: 18.1–84.8]

Consecutive

Radiography

Radiologist

No follow up

Can 2008 [6]

2008

Zurich

Prospective cohort study

251

51 ± 21 (fracture present)

38 ± 17 (fracture absent)

Consecutive

Radiography

Radiologist and emergency physicians

N/R

Cheng 2016 [7]

2016

Australia

Retrospective review

404

38.5

Consecutive

Radiography

N/R

N/R

Daş 2016 [8]

2016

Turkey

Retrospective case–control analysis

405

37.5

Consecutive

Radiography

Radiologist and Orthopaedic surgeon (blinded to OAR status)

No follow up

Glas 2002 [12]

2002

Amsterdam

Prospective comparative study

647

35 ± 14

Consecutive

Radiography

Radiologist and trauma surgeon

N/R

Gomes 2020 [13]

2000

Australia

Retrospective review

262

38 ± 13.8

Unclear

Radiography

Radiologist

N/R

Lucchesi 1995 [16]

1995

Michigan

Prospective validation study

484

38 [range: 18–81]

Convenience

Radiography

Radiologist

No follow up

Papacostas 2001 [21]

2001

Greece

Prospective survey

79

29 ± 9.6

Consecutive

Radiography

Radiologist

No follow up

Rosin 1999 [22]

1999

South Korea

Retrospective

67

24.9 [range: 19–41]

Consecutive

Radiography

N/R

N/R

Santelli 2008 [24]

2008

France

Prospective

248

31.8 ± 15.9

Consecutive

Radiography

Radiologist

N/R

Salt 1997 [23]

1997

UK

Prospective

324

Above 18

Consecutive

Radiography

N/R

No follow-up

Stiell 1994 [25]

1994

Canada

Non-randomized controlled trial

498

37 ± 16

Consecutive

Radiography

Radiologist

Telephoned at 10 days or asked to return for re-assessment

Verma 1997 [28]

1997

US

Retrospective

2500

Above 18

Consecutive

Radiography

N/R

Medical record review

Verma 1997 [28]

1997

US

Prospective

759

Above 18

Consecutive

Radiography

N/R

Telephone or medical record review

Wang 2013 [23]

2013

China

Prospective

183

36.6 [range:18–70]

Consecutive

Radiography

ED physician

3D CT

  1. ED Emergency department, N/R Not recorded, UK United Kingdom, US United States of America, 3D Three-dimensional, CT Computed tomography