Table 3 Association analysis between MIR31HG SNPs and SONFH risk
SNP ID | Model | Genotype | Case | Control | With Adjustment | |
|---|---|---|---|---|---|---|
OR (95% CI) | Pb | |||||
rs1332184 | Codominant | G/G | 109 | 276 | 1 | |
A/A | 7 | 37 | 0.49 (0.20–1.14) | 0.099 | ||
A/G | 84 | 194 | 1.05 (0.74–1.50) | 0.770 | ||
Dominant | G/G | 109 | 276 | 1 | ||
A/A-A/G | 91 | 231 | 0.96 (0.68–1.36) | 0.837 | ||
Recessive | A/G-G/G | 193 | 470 | 1 | ||
A/A | 7 | 37 | 0.47 (0.20–1.11) | 0.084 | ||
Log-additive | – | – | – | 0.88 (0.67–1.17) | 0.391 | |
rs72703442 | Codominant | C/C | 145 | 352 | 1 | |
A/A | 2 | 10 | 0.52 (0.11–2.49) | 0.414 | ||
A/C | 53 | 145 | 0.85 (0.58–1.25) | 0.417 | ||
Dominant | C/C | 145 | 352 | 1 | ||
A/A-A/C | 55 | 155 | 0.83 (0.57–1.22) | 0.342 | ||
Recessive | A/C-C/C | 198 | 497 | 1 | ||
A/A | 2 | 10 | 0.54 (0.11–2.59) | 0.446 | ||
Log-additive | – | – | – | 0.82 (0.58–1.17) | 0.285 | |
rs2025327 | Codominant | T/T | 159 | 391 | 1 | |
C/C | 2 | 7 | 0.61 (0.12–3.13) | 0.557 | ||
C/T | 39 | 110 | 0.84 (0.55–1.28) | 0.407 | ||
Dominant | T/T | 159 | 391 | 1 | ||
C/C-C/T | 41 | 117 | 0.82 (0.54–1.25) | 0.354 | ||
Recessive | C/T-T/T | 198 | 501 | 1 | ||
C/C | 2 | 7 | 0.64 (0.13–3.24) | 0.588 | ||
Log-additive | – | – | – | 0.82 (0.56–1.21) | 0.324 | |
rs55683539 | Codominant | C/C | 116 | 297 | 1 | |
T/T | 8 | 37 | 0.57 (0.25–1.29) | 0.176 | ||
T/C | 76 | 173 | 1.12 (0.78–1.60) | 0.536 | ||
Dominant | C/C | 116 | 297 | 1 | ||
T/T-T/C | 84 | 210 | 1.02 (0.73–1.45) | 0.893 | ||
Recessive | T/C-C/C | 192 | 470 | 1 | ||
T/T | 8 | 37 | 0.54 (0.24–1.22) | 0.139 | ||
Log-additive | – | – | – | 0.93 (0.71–1.24) | 0.629 | |
rs2181559 | Codominant | T/T | 87 | 213 | 1 | |
A/A | 20 | 70 | 0.64 (0.36–1.15) | 0.135 | ||
A/T | 92 | 225 | 1.05 (0.73–1.50) | 0.804 | ||
Dominant | T/T | 87 | 213 | 1 | ||
A/A-A/T | 112 | 295 | 0.95 (0.67–1.33) | 0.746 | ||
Recessive | A/T-T/T | 179 | 438 | 1 | ||
A/A | 20 | 70 | 0.63 (0.36–1.09) | 0.097 | ||
Log-additive | – | – | – | 0.87 (0.68–1.12) | 0.292 | |
rs10965059 | Codominant | C/C | 164 | 340 | 1 | |
T/T | 5 | 10 | 1.12 (0.36–3.49) | 0.842 | ||
T/C | 31 | 149 | 0.50 (0.32–0.78) | 0.002* | ||
Dominant | C/C | 164 | 340 | 1 | ||
T/T-T/C | 36 | 159 | 0.54 (0.35–0.82) | 0.004* | ||
Recessive | T/C-C/C | 195 | 489 | 1 | ||
T/T | 5 | 10 | 1.31 (0.42–4.07) | 0.644 | ||
Log-additive | – | – | – | 0.63 (0.43–0.92) | 0.016* | |
rs10965064 | Codominant | C/C | 80 | 203 | 1 | |
G/G | 23 | 71 | 0.82 (0.47–1.42) | 0.474 | ||
G/C | 97 | 234 | 1.00 (0.70–1.45) | 0.989 | ||
Dominant | C/C | 80 | 203 | 1 | ||
G/G-G/C | 120 | 305 | 0.96 (0.68–1.36) | 0.818 | ||
Recessive | G/C-C/C | 177 | 437 | 1 | ||
G/G | 23 | 71 | 0.81 (0.48–1.37) | 0.440 | ||
Log-additive | – | – | – | 0.93 (0.72–1.20) | 0.580 | |