Table 3 Results of the Knee injury and Osteoarthritis Outcome Score (KOOS) subscales at each visit showing means, standard deviations, medians and interquartile ranges as well as number of patients at each visit

Total

Paediatric

Adolescent

Adult

Paediatric vs Adolescent

Paediatric vs Adult

Adolescent vs Adult

- 1 year -

KOOS—Pain

83.4 (16.6)

88.9 (2.8; 100)

(82.5; 84.3)

n = 1365

88.5 (14.5)

94.4 (44.4; 100)

(82.7; 93.5)

n = 27

83.3 (16.7)

88.9 (25; 100)

(81.2; 85.2)

n = 275

83.3 (16.6)

88.9 (2.8; 100)

(82.3; 84.3)

n = 1063

0.10

0.091

0.98

KOOS—Symtom

76.8 (18.4)

82.1 (3.6; 100)

(75.8; 77.7)

n = 1365

82.3 (16.9)

85.7 (28.6; 100)

(75.7; 88.2)

n = 27

75.3 (18.6)

78.6 (14.3; 100)

(73.1; 77.5)

n = 275

77.0 (18.3)

82.1 (3.6; 100)

(75.9; 78.1)

n = 1063

0.054

0.13

0.18

KOOS—ADL

90.4 (14.1)

95.6 (0; 100)

(89.7; 91.2)

n = 1365

93.0 (11.5)

98.5 (55.9; 100)

(88.3; 96.8)

n = 27

90.8 (14.1)

97.1 (16.2; 100)

(89.1; 92.4)

n = 274

90.3 (14.2)

95.6 (0; 100)

(89.4; 91.1)

n = 1064

0.45

0.32

0.63

KOOS – Sports & recreation

63.2 (27.7)

70 (0; 100)

(61.7; 64.6)

n = 1365

72.4 (29.6)

85 (5; 100)

(60.7; 82.7)

n = 27

64.1 (27.7)

70 (0; 100)

(60.8; 67.3)

n = 274

62.7 (27.7)

70 (0; 100)

(61.1; 64.4)

n = 1064

0.14

0.070

0.48

KOOS – QoL

57.1 (24.1)

56.3 (0; 100)

(55.8; 58.4)

n = 1366

60.0 (29.7)

62.5 (12.5; 100)

(48.9; 71.0)

n = 27

55.4 (24.0)

56.3 (0; 100)

(52.6; 58.2)

n = 275

57.5 (24.0)

62.5 (0; 100)

(56.1; 58.9)

n = 1064

0.37

0.63

0.20

KOOS4

70.1 (19.4)

73.5 (9.1; 100)

(69.0; 71.1)

n = 1366

75.8 (19.9)

80.3 (22.6; 100)

(68.0; 82.8)

n = 27

69.5 (19.4)

72.2 (10.7; 100)

(67.1; 71.7)

n = 275

70.1 (19.4)

73.7 (9.1; 100)

(68.9; 71.2)

n = 1064

0.099

0.13

0.63

- 2 years -

KOOS—Pain

83.9 (16.9)

88.9 (11.1; 100)

(82.9; 84.8)

n = 1211

87.7 (13.2)

94.4 (58.3; 100)

(82.4; 92.4)

n = 25

81.4 (17.8)

86.1 (13.9; 100)

(79.0; 83.6)

n = 234

84.4 (16.7)

88.9 (11.1; 100)

(83.3; 85.4)

n = 952

0.067

0.34

0.017

KOOS—Symtom

78.2 (18.1)

82.1 (7.1; 100)

(77.2; 79.2)

n = 1211

82.3 (16.5)

85.7 (46.4; 100)

(75.7; 88.4)

n = 25

74.6 (18.5)

78.6 (10.7; 100)

(72.1; 77.0)

n = 234

78.9 (18.0)

82.1 (7.1; 100)

(77.7; 80.1)

n = 952

0.038

0.37

0.0014

KOOS—ADL

90.9 (14.2)

97.1 (2.9; 100)

(90.1; 91.7)

n = 1211

93.9 (9.4)

100 (69.1; 100)

(90.0; 97.3)

n = 25

90.2 (14.6)

95.6 (13.2; 100)

(88.3; 92.0)

n = 234

91.0 (14.2)

97.1 (2.9; 100)

(90.1; 91.9)

n = 952

0.20

0.31

0.42

KOOS – Sports & recreation

64.8 (27.5)

70 (0; 100)

(63.3; 66.4)

n = 1210

77.0 (24.5)

90 (25; 100)

(67.1; 85.9)

n = 25

62.8 (27.7)

65 (0; 100)

(59.2; 66.3)

n = 234

65.0 (27.5)

70 (0; 100)

(63.3; 66.8)

n = 951

0.011

0.026

0.27

KOOS – QoL

59.2 (23.9)

62.5 (0; 100)

(57.9; 60.6)

n = 1211

67.5 (26.3)

68.8 (25; 100)

(57.3; 77.5)

n = 25

55.0 (23.9)

56.3 (0; 100)

(52.0; 58.0)

n = 234

60.1 (23.7)

62.5 (0; 100)

(58.6; 61.6)

n = 952

0.016

0.13

0.0034

KOOS4

71.5 (19.7)

75.2 (6.2; 100)

(70.4; 72.6)

n = 1211

78.6 (18.2)

80.7 (43.7; 100)

(71.4; 85.4)

n = 25

68.4 (19.6)

69.3 (6.2; 100)

(65.9; 70.9)

n = 234

72.1 (19.7)

75.9 (8.6; 100)

(70.8; 73.3)

n = 952

0.0098

0.094

0.012

- 5 years -

KOOS—Pain

85.9 (16.4)

91.7 (13.9; 100)

(84.8; 87.0)

n = 822

83.6 (14.2)

86.1 (66.7; 100)

(74.1; 92.9)

n = 9

82.1 (18.3)

86.1 (19.4; 100)

(79.1; 84.9)

n = 156

86.8 (15.8)

91.7 (13.9; 100)

(85.6; 88.0)

n = 657

0.87

0.52

0.0018

KOOS—Symtom

81.0 (17.6)

85.7 (14.3; 100)

(79.8; 82.2)

n = 822

81.0 (14.9)

85.7 (53.6; 100)

(70.8; 90.1)

n = 9

75.7 (19.4)

78.6 (14.3; 100)

(72.6; 78.7)

n = 156

82.3 (16.9)

85.7 (14.3; 100)

(81.0; 83.6)

n = 657

0.45

0.77

0.0002

KOOS—ADL

92.1 (13.4)

98.5 (25; 100)

(91.2; 93.0)

n = 822

91.0 (10.8)

95.6 (70.6; 100)

(83.5; 97.6)

n = 9

90.1 (15.5)

97.1 (25; 100)

(87.6; 92.5)

n = 156

92.6 (12.8)

98.5 (26.5; 100)

(91.6; 93.6)

n = 657

0.96

0.64

0.046

KOOS – Sports & recreation

68.7 (26.4)

75 (0; 100)

(66.9; 70.5)

n = 822

74.4 (24.8)

75 (30; 100)

(57.1; 89.5)

n = 9

64.1 (27.7)

70 (0; 100)

(59.7; 68.4)

n = 156

69.7 (26.0)

75 (0; 100)

(67.7; 71.7)

n = 657

0.28

0.65

0.020

KOOS – QoL

63.7 (22.9)

68.8 (0; 100)

(62.1; 65.2)

n = 822

55.6 (20.6)

62.5 (25; 81.3)

(42.0; 68.8)

n = 9

57.3 (23.2)

59.4 (0; 100)

(53.7; 60.9)

n = 156

65.3 (22.6)

68.8 (0; 100)

(63.5; 67.1)

n = 657

0.86

0.22

0.0002

KOOS4

74.8 (19.0)

79.1 (11.8; 100)

(73.5; 76.1)

n = 822

73.6 (16.7)

71.2 (52.2; 92.2)

(62.6; 84.4)

n = 9

69.8 (20.2)

72.4 (11.8; 100)

(66.6; 72.9)

n = 156

76.0 (18.6)

80.5 (14.3; 100)

(74.6; 77.5)

n = 657

0.59

0.66

0.0006

- 10 years -

KOOS—Pain

87.7 (14.8)

91.7 (22.2; 100)

(85.9; 89.4)

n = 260

91.7 (4.8)

88.9 (88.9; 97.2)

(88.9; 97.2)

n = 3

83.0 (15.4)

86.1 (38.9; 100)

(78.5; 87.2)

n = 47

88.7 (14.5)

94.4 (22.2; 100)

(86.7; 90.6)

n = 210

0.38

0.92

0.025

KOOS—Symtom

83.8 (16.1)

89.3 (14.3; 100)

(81.8; 85.7)

n = 260

90.5 (7.4)

92.9 (82.1; 96.4)

(82.1; 96.4)

n = 3

79.0 (17.7)

82.1 (28.6; 100)

(73.6; 84.0)

n = 47

84.7 (15.6)

89.3 (14.3; 100)

(82.6; 86.7)

n = 210

0.28

0.64

0.034

KOOS—ADL

93.0 (12.3)

98.5 (42.7; 100)

(91.5; 94.5)

n = 260

97.6 (1.7)

98.5 (95.6; 98.5)

(95.6; 98.5)

n = 3

90.6 (13.6)

95.6 (51.5; 100)

(86.4; 94.2)

n = 47

93.5 (12.0)

98.5 (42.7; 100)

(91.8; 95.1)

n = 210

0.47

0.84

0.15

KOOS – Sports & recreation

69.3 (26.7)

75 (0; 100)

(66.2; 72.6)

n = 260

80.0 (8.7)

85 (70; 85)

(70.0; 85.0)

n = 3

59.3 (28.5)

60 (0; 100)

(50.8; 67.5)

n = 47

71.5 (26.0)

75 (0; 100)

(67.9; 74.9)

n = 210

0.24

0.70

0.0058

KOOS – QoL

66.3 (23.9)

75 (0; 100)

(63.5; 69.1)

n = 260

72.9 (21.9)

75 (50; 93.8)

(50.0; 93.8)

n = 3

57.7 (24.8)

62.5 (6.3; 100)

(50.6; 64.8)

n = 47

68.1 (23.4)

75 (0; 100)

(65.0; 71.2)

n = 210

0.36

0.86

0.0085

KOOS4

76.8 (18.6)

82.4 (10.4; 100)

(74.6; 79.0)

n = 260

83.8 (10.3)

85.4 (72.8; 93.1)

(72.8; 93.1)

n = 3

69.8 (19.5)

72.6 (26; 98.4)

(64.0; 75.3)

n = 47

78.2 (18.2)

83.9 (10.4; 100)

(75.8; 80.6)

n = 210

0.22

0.70

0.0058