From: Characteristics of clinical trials related to hip fractures and factors associated with completion
Characteristics | Completion time (median, days) | Simple Cox regression | Multiple Cox regression | Multiple Cox regressiona | |||
---|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | ||
Outcome measures including mortality | |||||||
Yes | 1430.00 | 0.66 (0.52–0.84) | < 0.01 | 0.89 (0.67–1.17) | 0.40 | 0.83 (0.57–1.22) | 0.34 |
No | 823.00 | ||||||
Gender | |||||||
Male | 122.00 | 1.42 (0.89–2.26) | 0.13 | 1.05 (0.67–1.66) | 0.83 | 0.87 (0.47–1.64) | 0.67 |
Female | 1065.00 | ||||||
Both | 931.00 | ||||||
Age including children | |||||||
Yes | 882.00 | 0.97 (0.70–1.34) | 0.84 | 1.00 (0.70–1.43) | 1.00 | 0.83 (0.52–1.34) | 0.45 |
No | 945.00 | ||||||
Age including older adults | |||||||
Yes | 931.00 | 1.00 (0.51–1.93) | 0.99 | 1.56 (0.74–3.27) | 0.24 | 0.87 (0.24–3.18) | 0.83 |
No | 1096.00 | ||||||
Phases | |||||||
Not applicable | 973.00 | 1.09 (1.03–1.16) | < 0.01 | 1.06 (0.98–1.14) | 0.16 | 1.07 (0.96–1.19) | 0.22 |
Phase 1 | 360.00 | ||||||
Phase 2 | 1055.00 | ||||||
Phase 3 | 1036.00 | ||||||
Phase 4 | 731.00 | ||||||
Enrollment | |||||||
≤ 50 | 671.00 | 0.76 (0.71–0.82) | < 0.01 | 0.77 (0.70–0.84) | < 0.01 | 0.80 (0.71–0.90) | < 0.01 |
> 50 and ≤ 100 | 725.00 | ||||||
> 100 and ≤ 200 | 1096.00 | ||||||
> 200 and ≤ 400 | 1308.00 | ||||||
> 400 | 1646.00 | ||||||
Funded by the NIH | |||||||
Yes | 2007.00 | 0.44 (0.27–0.70) | < 0.01 | 0.47 (0.28–0.82) | 0.01 | 0.41 (0.22–0.78) | 0.01 |
No | 894.00 | ||||||
Funded by industry | |||||||
Yes | 762.00 | 0.88 (0.69–1.14) | 0.33 | 0.96 (0.72–1.28) | 0.79 | 1.09 (0.74–1.60) | 0.66 |
No | 945.00 | ||||||
Allocation | |||||||
Not applicable | 700.00 | 0.92 (0.80–1.06) | 0.27 | 0.92 (0.72–1.18) | 0.52 | 0.91 (0.65–1.28) | 0.59 |
Non-randomized | 851.00 | ||||||
Randomized | 1003.00 | ||||||
Intervention model | |||||||
Single | 819.00 | 1.01 (0.91–1.13) | 0.83 | 1.13 (0.95–1.35) | 0.16 | 1.18 (0.93–1.49) | 0.18 |
Sequential | 744.00 | ||||||
Parallel | 1004.00 | ||||||
Factorial | 1065.00 | ||||||
Crossover | 365.00 | ||||||
Masking | |||||||
None | 941.00 | 1.09 (1.01–1.17) | 0.02 | 1.00 (0.92–1.10) | 0.93 | 0.98 (0.87–1.11) | 0.75 |
Single | 1037.00 | ||||||
Double | 819.00 | ||||||
Triple | 671.00 | ||||||
Quadruple | 1055.00 | ||||||
Primary purpose | |||||||
Diagnostic | |||||||
Yes | 638.00 | 1.78 (1.08–2.94) | 0.04 | 1.35 (0.66–2.74) | 0.41 | 1.73 (0.60–5.00) | 0.31 |
No | 950.00 | ||||||
Health service research | |||||||
Yes | 950.00 | 0.98 (0.56–1.70) | 0.94 | 0.81 (0.39–1.70) | 0.58 | 0.62 (0.20–1.89) | 0.40 |
No | 931.00 | ||||||
Prevention | |||||||
Yes | 822.00 | 1.08 (0.85–1.39) | 0.53 | 1.01 (0.59–1.71) | 0.98 | 0.94 (0.44–2.01) | 0.88 |
No | 1003.00 | ||||||
Supportive care | |||||||
Yes | 747.00 | 1.24 (0.84–1.83) | 0.30 | 1.10 (0.60–2.02) | 0.76 | 0.88 (0.38–2.04) | 0.77 |
No | 945.00 | ||||||
Treatment | |||||||
Yes | 1047.00 | 0.83 (0.68–1.01) | 0.06 | 0.76 (0.46–1.24) | 0.26 | 0.75 (0.37–1.52) | 0.42 |
No | 762.00 | ||||||
Interventions | |||||||
Behavioral | |||||||
Yes | 882.00 | 0.96 (0.68–1.37) | 0.83 | 1.16 (0.78–1.72) | 0.46 | 0.95 (0.58–1.55) | 0.82 |
No | 941.00 | ||||||
Drug/biological | |||||||
Yes | 731.00 | 1.57 (1.28–1.92) | < 0.01 | 1.48 (1.07–2.05) | 0.02 | 1.50 (0.96–2.35) | 0.07 |
No | 1035.00 | ||||||
Device | |||||||
Yes | 1096.00 | 0.71 (0.58–0.88) | < 0.01 | 0.93 (0.70–1.24) | 0.63 | 0.91 (0.60–1.40) | 0.68 |
No | 866.00 | ||||||
Procedure | |||||||
Yes | 914.00 | 0.98 (0.80–1.20) | 0.83 | 1.07 (0.82–1.40) | 0.60 | 0.75 (0.50–1.14) | 0.17 |
No | 931.00 | ||||||
Location in China | |||||||
Yes | 866.00 | 1.25 (0.92–1.71) | 0.17 | 0.93 (0.64–1.34) | 0.68 | 0.56 (0.28–1.10) | 0.09 |
No | 973.00 | ||||||
Location in the United States | |||||||
Yes | 1125.00 | 0.79 (0.63–0.99) | 0.03 | 0.63 (0.46–0.87) | < 0.01 | 0.56 (0.35–0.90) | 0.02 |
No | 882.00 | ||||||
Location in Europe | |||||||
Yes | 1065.00 | 0.82 (0.68–0.98) | 0.03 | 0.62 (0.48–0.81) | < 0.01 | 0.51 (0.35–0.76) | < 0.01 |
No | 821.00 | ||||||
Location in Canada | |||||||
Yes | 931.00 | 1.09 (0.75–1.57) | 0.66 | 0.69 (0.45–1.05) | 0.08 | 0.54 (0.30–0.97) | 0.04 |
No | 945.00 |