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Table 3 Associations of IL1B and IL6 gene variants with postoperative outcome

From: Genetic variants of interleukin 1B and 6 are associated with clinical outcome of surgically treated lumbar degenerative disc disease

SNP

Genotype

dODI

p

dPAIN

p

GTO

p

Surgical outcome

p

adjusted p-value

 

(N)

Mean+SD

Mean+SD

good

N (%)

poor

N (%)

good

N (%)

poor

N (%)

IL1B_rs3917365

C/C (358)

T/C (71)

T/T (1)

23.1+23.6

24.5+22.23

2.2

0.963

-3.3+3.2

-3.7+3.3

-2.2

0.444

269 (76.2%)

50 (83.3%)

NA

84 (13.8%)

10 (16.4%)

NA

0.861

321 (89.6%)

64 (90.1%)

1

37 (10.4%)

7 (9.9%)

0

0.874

0.951

IL1B_rs1143634

C/C (233)

C/T (166)

T/T (31)

23.2+23.2

22.6+23.4

27.3+25.1

0.353

-3.6+3.2

-3.1+3.3

-3.4+3.3

0.387

175 (83.0%)

119 (80.0%)

24 (80%)

36 (17.0%)

30 (20.0%)

6 (20%)

0.477

212 (90.99%)

146 (87.95%)

27 (90%)

21 (9.01%)

20 (12.05%)

3 (10%)

0.334

0.253

IL1B_rs1143633

G/G (184)

A/G (187)

A/A (41)

22.4+.22.2

23.2+24.8

25.2+21.2

0.311

-2.9+3.2

-3.6+3.3

-4.1+3.2

0.00085*

136 (82.0%)

138 (80.7%)

44 (84.6%)

30 (18.0%)

33 (19.3%)

8 (16.4%)

0.585

166 (90.3%)

165 (88.2%)

52 (94.5%)

18 (9.7%)

22 (11.8%)

3 (5.5%)

0.188

0.249

IL1B_rs1143627

T/T (184)

T/C (196)

C/C (50)

24.4+24.0

22.0+23.6

24.3+20.4

0.133

-3.4+3.4

-3.3+3.0

-3.4+3.5

0.412

135 (78.0%)

144 (83.2%)

40 (88.9%)

38 (22.0%)

29 (16.8%)

5 (11.1%)

0.049Æ’

167 (90.8%)

174 (88.7%)

45 (90%)

17 (9.2%)

22 (11.3%)

5 (10%)

0.535

0.556

IL1B_rs16944

G/G (182)

A/G (191)

A/A (49)

24.1+24.0

22.2+23.7

24.2+20.6

0.176

-3.4+3.5

-3.3+3.0

-3.4+3.5

0.486

144 (79.1%)

155 (82.9%)

42 (89.4%)

38 (20.9%)

32 (17.1%)

5 (10.6%)

0.056

165 (90.66%)

169 (88.5%)

44 (89.8%)

17 (9.34%)

22 (11.5%)

5 (10.2%)

0.505

0.516

IL6_rs2069852

G/G (389)

G/A (42)

A/A (0)

22.9+23.0

26.3+26.5

-

0.734

-3.4+3.2

-3.3+3.4

0.397

292 (82.5%)

28 (73.7%)

0

62 (17.5%)

10 (22.3%)

0

0.144

346 (88.9%)

41 (97.6%)

43 (11.1%)

1 (3.4%)

0.039†

0.06

IL6_rs2069861

C/C (376)

T/C (51)

T/T (2)

23.7+23.7

21.1+21.3

13+12.7

0.261

-3.3+3.3

-3.5+2.9

-2.4+5.7

0.360

278 (81.3%)

39 (86.6%)

2

65 (18.7%)

6 (13.4%)

0

0.403

334 (88.8%)

50 (98%)

1 (50%)

42 (11.2%)

1 (2%)

1 (50%)

0.014**

0.004**

IL6_rs2069835

C/C (4)

T/C (54)

T/T (367)

5.1+9.7

19.9+21.6

23.9+23.5

0.351

-4.2+3.0

-2.9+3.1

-3.4+3.2

0.153

3 (75%)

36 (79.5%)

277 (83.1%)

1 (25%)

13 (20.5%)

56 (16.9%)

0.569

2 (50%)

46 (85.2%)

334 (88.7%)

2 (50%)

8 (14.8%)

33 (8.9%)

0.027Æ’

0.05 Æ’

IL6_rs1800796

G/G (371)

G/C (54)

C/C (1)

22.7+22.8

25.7+26.4

32

0.548

-3.4+3.2

-3.4+3.4

-1.8

0.486

279 (82.5%)

36 (75.0%)

1

59 (17.5%)

12 (25.0%)

0

0.165

329 (88.7%)

53 (98%)

1

42 (11.3%)

1 (2%)

0

0.009*

0.03*

  1. *: significant in dominant model, **: significant in overdominant model, †: significant in codominant model, ‡: significant in recessive model, ƒ: significant in log-additive model