SNP | Genotype | dODI | p | dPAIN | p | GTO | p | Surgical outcome | p | adjusted p-value | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 | (N) | Mean+SD | Mean+SD | good N (%) | poor N (%) | good N (%) | poor N (%) | |||||
IL1B_rs3917365 | C/C (358) T/C (71) T/T (1) | 23.1+23.6 24.5+22.23 2.2 | 0.963 | -3.3+3.2 -3.7+3.3 -2.2 | 0.444 | 269 (76.2%) 50 (83.3%) NA | 84 (13.8%) 10 (16.4%) NA | 0.861 | 321 (89.6%) 64 (90.1%) 1 | 37 (10.4%) 7 (9.9%) 0 | 0.874 | 0.951 |
IL1B_rs1143634 | C/C (233) C/T (166) T/T (31) | 23.2+23.2 22.6+23.4 27.3+25.1 | 0.353 | -3.6+3.2 -3.1+3.3 -3.4+3.3 | 0.387 | 175 (83.0%) 119 (80.0%) 24 (80%) | 36 (17.0%) 30 (20.0%) 6 (20%) | 0.477 | 212 (90.99%) 146 (87.95%) 27 (90%) | 21 (9.01%) 20 (12.05%) 3 (10%) | 0.334 | 0.253 |
IL1B_rs1143633 | G/G (184) A/G (187) A/A (41) | 22.4+.22.2 23.2+24.8 25.2+21.2 | 0.311 | -2.9+3.2 -3.6+3.3 -4.1+3.2 | 0.00085* | 136 (82.0%) 138 (80.7%) 44 (84.6%) | 30 (18.0%) 33 (19.3%) 8 (16.4%) | 0.585 | 166 (90.3%) 165 (88.2%) 52 (94.5%) | 18 (9.7%) 22 (11.8%) 3 (5.5%) | 0.188 | 0.249 |
IL1B_rs1143627 | T/T (184) T/C (196) C/C (50) | 24.4+24.0 22.0+23.6 24.3+20.4 | 0.133 | -3.4+3.4 -3.3+3.0 -3.4+3.5 | 0.412 | 135 (78.0%) 144 (83.2%) 40 (88.9%) | 38 (22.0%) 29 (16.8%) 5 (11.1%) | 0.049Æ’ | 167 (90.8%) 174 (88.7%) 45 (90%) | 17 (9.2%) 22 (11.3%) 5 (10%) | 0.535 | 0.556 |
IL1B_rs16944 | G/G (182) A/G (191) A/A (49) | 24.1+24.0 22.2+23.7 24.2+20.6 | 0.176 | -3.4+3.5 -3.3+3.0 -3.4+3.5 | 0.486 | 144 (79.1%) 155 (82.9%) 42 (89.4%) | 38 (20.9%) 32 (17.1%) 5 (10.6%) | 0.056 | 165 (90.66%) 169 (88.5%) 44 (89.8%) | 17 (9.34%) 22 (11.5%) 5 (10.2%) | 0.505 | 0.516 |
IL6_rs2069852 | G/G (389) G/A (42) A/A (0) | 22.9+23.0 26.3+26.5 - | 0.734 | -3.4+3.2 -3.3+3.4 | 0.397 | 292 (82.5%) 28 (73.7%) 0 | 62 (17.5%) 10 (22.3%) 0 | 0.144 | 346 (88.9%) 41 (97.6%) | 43 (11.1%) 1 (3.4%) | 0.039†| 0.06 |
IL6_rs2069861 | C/C (376) T/C (51) T/T (2) | 23.7+23.7 21.1+21.3 13+12.7 | 0.261 | -3.3+3.3 -3.5+2.9 -2.4+5.7 | 0.360 | 278 (81.3%) 39 (86.6%) 2 | 65 (18.7%) 6 (13.4%) 0 | 0.403 | 334 (88.8%) 50 (98%) 1 (50%) | 42 (11.2%) 1 (2%) 1 (50%) | 0.014** | 0.004** |
IL6_rs2069835 | C/C (4) T/C (54) T/T (367) | 5.1+9.7 19.9+21.6 23.9+23.5 | 0.351 | -4.2+3.0 -2.9+3.1 -3.4+3.2 | 0.153 | 3 (75%) 36 (79.5%) 277 (83.1%) | 1 (25%) 13 (20.5%) 56 (16.9%) | 0.569 | 2 (50%) 46 (85.2%) 334 (88.7%) | 2 (50%) 8 (14.8%) 33 (8.9%) | 0.027Æ’ | 0.05 Æ’ |
IL6_rs1800796 | G/G (371) G/C (54) C/C (1) | 22.7+22.8 25.7+26.4 32 | 0.548 | -3.4+3.2 -3.4+3.4 -1.8 | 0.486 | 279 (82.5%) 36 (75.0%) 1 | 59 (17.5%) 12 (25.0%) 0 | 0.165 | 329 (88.7%) 53 (98%) 1 | 42 (11.3%) 1 (2%) 0 | 0.009* | 0.03* |