Table 2 Associations of IL1B and IL6 gene variants with preoperative PROMs

IL1B_rs3917365

C/C (358)

T/C (71)

T/T (1)

39.5+8.2

39.6+7.1

63

0.146

8.3+5.8

8.2+4.9

22

0.832

47.5+18.7

47.1+16.7

60

0.78

7.2+2.0

7.2+1.9

8

0.69

IL1B_rs1143634

C/C (233)

C/T (166)

T/T (31)

39.0+7.8

40.7+8.4

38.4+7.9

0.025^**

8.2+5.7

8.3+5.3

9.3+7.4

0.401

47.1+17.9

47.7+19.0

48.3+18.5

0.655

7.3+1.9

7.1+2.0

7.0+2.1

0.253

IL1B_rs1143633

G/G (184)

A/G (187)

A/A (41)

39.4+8.1

39.9+7.8

39.7+9.0

0.526

8.6+5.6

7.9+5.4

8.9+6.9

0.183

47.1+17.9

47.4+19.2

47.6+16.0

0.813

7.1+2.0

7.3+1.8

7.4+2.0

0.170

IL1B_rs1143627

T/T (184)

T/C (196)

C/C (50)

40.6+8.7

39.2+7.3

38.0+8.0

0.025^ƒ

8.0+5.5

8.5+5.8

8.6+5.6

0.371

48.8+18.2

46.0+18.8

48.3+16.9

0.135

7.1+2.1

7.3+1.8

7.2+2.2

0.338

IL1B_rs16944

G/G (182)

A/G (191)

A/A (49)

40.6+8.8

39.2+7.3

38.0+8.0

0.025^ƒ

8.0+5.5

8.5+5.9

8.5+5.6

0.424

48.6+18.2

46.3+19.0

48.5+17.0

0.207

7.1+2.1

7.3+1.8

7.3+2.2

0.253

IL6_rs2069852

G/G (389)

G/A (42)

A/A (0)

39.7+8.0

39.1+8.7

-

0.629

8.4+5.8

7.0+4.4

-

0.192

47.2+18.3

59.8+18.5

-

0.375

7.2+2.0

7.1+2.0

-

0.623

IL6_rs2069861

C/C (376)

T/C (51)

T/T (2)

39.7+8.0

39.4+8.5

33.5+0.7

0.282

8.5+5.8

7.3+4.7

n/a

0.103

47.9+18.5

43.5+16.2

26+25.5

0.095

7.2+1.9

7.1+2.1

5.4+4.2

0.191

IL6_rs2069835

C/C (4)

T/C (54)

T/T (367)

45.3+10.1

42.2+9.2

39.2+7.8

0.003^ƒ

10.0+10.7

10.2+6.9

8.0+5.3

0.010^*

39.5+31.8

48.5+18.4

47.2+18.2

0.393

8.1+1.3

7.2+1.6

7.2+2.0

0.385

IL6_rs1800796

G/G (371)

G/C (54)

C/C (1)

39.8+8.0

38.4+8.6

40

0.239

8.5+5.7

6.8+4.7

14

0.087

47.0+18.1

50.2+19.3

40

0.208

7.2+2.0

7.1+1.9

4.4

0.149