Fig. 2
From: FK506 increases susceptibility to musculoskeletal infection in a rodent model
The effect of FK506 on immune function. The primary mechanism of FK506 is to inhibit the IL-2 production that is required for CD4+ T lymphocyte activation and function. In such a case, TNF-α and IFNγ expression are reduced. Lack of CD4+ T lymphocyte activation leads to decreased phagocytic activity of macrophages. Additionally, FK506 also effects neutrophil activation by attenuating Toll-like receptors (TLR) responses required for the innate immune responses