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Table 2 Risk factor for the infection outcome according to univariate analysis

From: Prior use of antibiotics and immunosuppression are risk factors for fracture-related infection during the COVID-19 pandemic period: a Brazilian prospective cohort study

Analyzed variable

Not Infected (n = 111)

Infected (n = 21)

p-value

Demography

N (%)

N (%)

 

 Male

84 (75.8)

15 (71.43)

0.680*

 Age (average-years)

50.8

48.5

0.651**

 P50(p25-p75)

44.0 (31.0; 72.0)

48.0 (30.5; 64.0)

Comorbidities

 Habit of smoking

30 (27.0)

5 (23.8)

0.759

 Alcoholism

29 (26.1)

4 (19.0)

0.492*

 Arterial hypertension

23 (20.7)

7 (33.3)

0.255***

 Cancer

3 (2.7)

2 (9.5)

0.179***

Perioperative risk

 Classification ASAb

  1

83 (74.7)

14 (66.6)

0.440*

   ≥ 2

28 (25.2)

7 (33.3)

 

 Charlson indexa

  Up to 4

88 (79.2)

18 (85.7)

0.763***

  Over 4

22 (19.8)

3 (14.2)

 

Associated with trauma

 Mechanism of injury

  Fall from one's own height

38 (3.4)

2 (9.5)

 

  Motorbike/car accident

47 (42.3)

9 (42.8)

0.023***

  Fall from height

4 (3.6)

3 (14.2)

  Open fracture

23 (20.7)

13(61.9)

 < 0.001*

  Closed fracture

88 (91.7)

8 (8.3)

 

 Gustilo-Anderson

  I

4 (3.6)

2 (9.5)

 

  II

4 (3.6)

1 (4.7)

0.688*

  III A, B and C

15 (13.5)

10 (47.6)

 

  External fixatora

18 (16.2)

9 (42.8)

0.015***

  Low Limber fracture

88 (79.2)

18 (85.7)

0.861***

  Time interval Fracture-surgery(h)

87.8 ± 119.8

93.3 ± 118,8

0.847**

  Average p50 (p25 – p75)

48 (24; 96)

24 (12; 121.5)

 

Perioperative data

 Type of osteosynthesis

  Plate and screw

43 (38.7)

15 (71.4)

0.006*

  Locked intramedullary nail (IMN)

68 (61.2)

6 (28.5)

 

  Recent preoperative use of ATB

1 (0.9)

4 (19.0)

0.002***

  Infection by covid

2 (1.8)

3 (14.2)

0,028***

  1. The probability of significance refers to the Chi-square test (*), Student's t test (**), Fisher's exact test (***), a—one undisclosed patient, ASAb American Society of Anesthesiologists, ATB Antibiotic