Table 5 Diagnostic performance of the tested markers in combination
Combinations | AUC (95% CI) | Youden index | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|
Combination of two markers | ||||||
CRP + ESR | 0.847(0.751–0.943) | 0.618 | 84.4% | 77.4% | 79.5% | 83.2% |
CRP + FIB | 0.897(0.816–0.978) | 0.685 | 75.0% | 93.5% | 92.3% | 78.4% |
CRP + NLR | 0.840(0.739–0.941) | 0.680 | 93.8% | 74.2% | 79.0% | 92.1% |
ESR + FIB | 0.890(0.809–0.971) | 0.619 | 81.3% | 80.6% | 81.2% | 80.7% |
ESR + NLR | 0.839(0.742–0.936) | 0.582 | 90.6% | 61.3% | 70.7% | 86.3% |
FIB + NLR | 0.900(0.818–0.982) | 0.712 | 93.8% | 77.4% | 81.0% | 92.1% |
Combination of three markers | ||||||
CRP + ESR + FIB | 0.896(0.819–0.973) | 0.656 | 68.8% | 96.9% | 95.8% | 75.1% |
ESR + FIB + NLR | 0.888(0.806–0.970) | 0.681 | 87.5% | 80.6% | 82.3% | 86.2% |
FIB + NLR + CRP | 0.905(0.827–0.984) | 0.746 | 87.5% | 87.1% | 87.5% | 87.1% |
NLR + CRP + ESR | 0.860(0.773–0.947) | 0.558 | 71.9% | 83.9% | 82.2% | 74.3% |
Combination of four markers | ||||||
CRP + ESR + FIB + NLR | 0.903(0.830–0.977) | 0.684 | 78.1% | 90.3% | 89.3% | 80.0% |