Fig. 5From: Intra-articular injection of monoiodoacetate induces diverse hip osteoarthritis in rats, depending on its doseOARSI scores, based on MIA dose. a–b With 0.25 mg and 0.5 mg of MIA, OARSI scores increased in a time-dependent manner, except for the score at 1–2 weeks in the 0.25-mg MIA group. c–d With 1.0 mg and 2.0 mg of MIA administration, time-dependent increases in OARSI scores were observed until 4 weeks after MIA injection. e With 4.0 mg of MIA administration, OARSI scores reached the maximum after 4 weeks. There were no significant differences among the four-week, eight-week, and 12-week groups. Data are presented as mean ± SEM, n = 6 rats per group. Data were analyzed using two-way ANOVA, followed by the Tukey–Kramer method. **, p < 0.01 (vs. 1 week group). §§, p < 0.01 (vs. two-week group). ¶¶, p < 0.01 (vs. four-week group). ††, p < 0.01 (vs. eight-week group). Abbreviations: OARSI, Osteoarthritis Research Society International; MIA, monoiodoacetate; SEM, standard error of the meanBack to article page