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Fig. 1 | BMC Musculoskeletal Disorders

Fig. 1

From: Intra-articular injection of monoiodoacetate induces diverse hip osteoarthritis in rats, depending on its dose

Fig. 1

KG grades at each time point. ae The KL classification grades at each time point, based on the dose of MIA. At each time point, the KL grades in the 2.0-mg and 4.0-mg MIA groups were significantly higher than those in the 0.25-mg and 0.5-mg MIA groups. At 8 weeks after MIA injection, the KL grades approached 4 in the groups receiving 2 mg MIA or more. At 12 weeks, the KL grades reached 4 in the groups receiving more than 1 mg of MIA. Data are presented as mean ± SEM, n = 6 rats per group. Data were analyzed using two-way ANOVA, followed by the Tukey–Kramer method. *, p < 0.05; **, p < 0.01 (vs. 0.25-mg MIA group). §, p < 0.05; §§, p < 0.01 (vs. 0.5-mg MIA group). ¶, p < 0.05; ¶¶, p < 0.01 (vs. 1.0-mg MIA group). †, p < 0.05; ††, p < 0.01 (vs. 2.0-mg MIA group). Abbreviations: KL, Kellgren and Lawrence system; MIA, monoiodoacetate; SEM, standard error of the mean

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