A genetic correlation scan identifies blood proteins associated with bone mineral density

Table 2 List of human plasma proteins identified by LDSC^a for Life course BMD^b

Plasma protein	Gene	15 less age group		30 ~ 45 age group		45 ~ 60 age group		60 more age group
Plasma protein	Gene	Coefficients	P value	Coefficients	P value	Coefficients	P value	Coefficients	P value
Myomesin-2	MYOM2	0.3755	0.0328	\	\	\	\	\	\
Periostin	POSTN	\	\	−0.5694	0.0192	\	\	\	\
Glyceraldehyde-3-phosphate Dehydrogenase, testis-specific	G3PT	\	\	0.6272	0.0315	\	\	\	\
Fas apoptotic inhibitory molecule 3	FAIM3	\	\	−0.3988	0.0341	\	\	\	\
RING finger protein 148	RN148	\	\	0.4332	0.0424	\	\	\	\
Interferon regulatory factor 1	IRF1	\	\	−0.4638	0.0459	\	\	\	\
Dynein light chain 1, cytoplasmic	DLC8	\	\	0.6325	0.0481	\\		\	\
Plexin-B2	PLXB2	\	\	0.5184	0.0488	0.3927	0.0348	\	\
Transmembrane glycoprotein NMB	GPNMB	\	\	\	\	0.4921	0.008	\	\
Carbohydrate sulfotransferase 15	CHST15	\	\	\	\	0.4835	0.0151	\	\
Testican-2	SPOCK2	\	\	\	\	0.3097	0.0332	\	\
ERO1-like protein beta	ERO1B	\	\	\	\	−0.3512	0.0419	\	\
Myosin-binding protein C, slow-type	MYBPC1	\	\	\	\	0.2941	0.0464	\	\
Stem Cell Growth Factor-beta	SCGF-beta	\	\	\	\	−0.4148	0.0468	\	\
Protein deglycase DJ-1	PARK7	\	\	\	\	\	\	−0.3613	0.0052
Coagulation Factor X	F10	\	\	\	\	\	\	−0.4772	0.0271
Metalloproteinase inhibitor 4	TIMP-4	\	\	\	\	\	\	−0.4097	0.0483

ISSN: 1471-2474