Table 1 Microstructure parameters of L3 in different groups of rats at 4-week and 8-week of CSII treatments

BMD (g cm⁻³)

4 weeks

0.20 (0.18–0.20)

0.18 (0.18–0.20)

0.18 (0.17–0.19)

0.21 (0.20–0.21)

8 weeks

0.21 (0.19–0.23)

0.18 (0.17–0.21)

0.16 (0.15–0.19) ^*

0.23 (0.20–0.25)

BV/TV (%)

4 weeks

27.88 (26.36–30.39)

26.99 (24.81–31.27)

26.86 (24.35–27.73)

32.88 (32.27–33.48)

8 weeks

31.71 (28.33–35.89)

27.23 (25.71–31.79)

23.43 (22.07–26.90) ^*

36.50 (30.49–39.01)

SMI

4 weeks

0.84 (0.81–1.17)

0.96 (0.76–1.11)

1.13 (1.04–1.25)

0.78 (0.78–0.78)

8 weeks

0.77 (0.50–0.85)

0.84 (0.81–1.17)

1.20 (1.08–1.33)

0.38 (0.17–0.88)

Tb.Th (mm)

4 weeks

0.09 (0.09–0.09)

0.09 (0.09–0.09)

0.08 (0.08–0.09) ^*

0.10 (0.10–0.10) ^@

8 weeks

0.10 (0.09–0.10)

0.09 (0.08–0.09)

0.08 (0.08–0.08) ^*

0.10 (0.09–0.11)

Tb.N (mm⁻¹)

4 weeks

3.27 (3.18–3.38)

3.10 (3.02–3.44)

3.13 (3.05–3.28)

3.20 (3.17–3.23)

8 weeks

3.33 (3.32–3.45)

3.11 (2.90–3.38)

3.04 (2.79–3.15)

3.54 (3.26–3.56)

Tb.Sp (mm)

4 weeks

0.24 (0.22–0.25)

0.24 (0.23–0.25)

0.25 (0.24–0.26)

0.23 (0.22–0.23)

8 weeks

0.23 (0.22–0.24)

0.24 (0.23–0.27)

0.25 (0.23–0.28)

0.22 (0.21–0.23)