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Fig. 2 | BMC Musculoskeletal Disorders

Fig. 2

From: A multimodality intervention to improve musculoskeletal health, function, metabolism, and well-being in spinal cord injury: study protocol for the FIT-SCI randomized controlled trial

Fig. 2

Conceptual Model for Hypothesized Effects of Multimodality Intervention in SCI. Exercise (FES-LC + AE) and testosterone may individually increase aerobic capacity, and muscle mass and strength, which would improve physical function and wellbeing. Exercise or testosterone may also enhance metabolic adaptations directly through effects on muscle mass and contractility mediated via myokines, fuel utilization, and other mechanisms, and indirectly via increased activity. Testosterone may directly affect metabolism and wellbeing. When combined, the synergistic effects of the multimodality intervention (FES-LC + AE + testosterone) may induce greater benefits compared to each intervention alone (as shown by larger solid arrows)

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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