Fig. 1From: Can metformin relieve tibiofemoral cartilage volume loss and knee symptoms in overweight knee osteoarthritis patients? Study protocol for a randomized, double-blind, and placebo-controlled trialFlowchart of the trial. #MRI, questionnaires, and body composition will be acquired. ☩262 participants will be enrolled and equally allocated to the two groups (131 per group) in this trial; however, the number of participants actually enrolled may vary slightly. *The follow-up will be carried out at 3, 6, 12, and 24 months, with questionnaires and body composition being acquired at 3, 6, 12, and 24 months, hematological measurements being acquired at 6, 12, and 24 months, and MRI being acquired at 24 monthsBack to article page