Association of bone-related biomarkers with femoral neck bone strength

Table 1 Comparison of general clinical information of the patients in each group

Parameters	Normal ^a (n = 27, fragility fracture n = 0)	Osteopenia ^b (n = 27, fragility fracture n = 0)	Osteoporosis ^c (n = 27, fragility fracture n = 15)	Severe osteoporosis ^d (n = 27, fragility fracture n = 27)	P-value
Gender (male/female)	6/21	7/20	6/21	5/22	0.934
Age (years)	51.48 ± 10.71	60.30 ± 6.03^*	63.00 ± 9.05^*	69.30 ± 8.97^*#	< 0.0001
BMI (kg/cm²)	24.85 ± 3.57	24.76 ± 3.89	24.88 ± 2.78	23.72 ± 3.37	0.545
Femoral neck BMD (g/cm²)	0.94 ± 0.12	0.80 ± 0.10^*	0.77 ± 0.09^*	0.61 ± 0.10^*#▲	< 0.0001
Femoral neck T-score	0.00 ± 0.90	-1.50 ± 0.48^*	-1.75 ± 0.75^*	-2.91 ± 0.40^*#▲	< 0.0001
Femoral neck L_max (KN)	3.00 ± 0.52	1.67 ± 0.46^*	1.12 ± 0.26^*	0.59 ± 0.19^*#▲	< 0.0001

Data are presented as the mean ± SD for age, BMI, femoral neck BMD, femoral neck T-score and femoral neck L_max
^a T-score ≥ -1.0
^b T-score < -1.0 and > -2.5
^c At least one of the following criteria fulfilled: (a) T-score ≤ -2.5; (b) femoral neck fragile fracture)
^d Fragility fracture with a T-score ≤ -2.5
^*P < 0.05, compared with normal group
^#P < 0.05, compared with osteopenia group
^▲P < 0.05, compared with osteoporosis group
BMI body mass index, BMD bone mineral density

ISSN: 1471-2474