Table 2 Clinical characteristics of IMNM and other types of IIM
Characteristics | IMNM(n = 68) | DM(n = 346) | ASS(n = 82) | PM(n = 32) | sIBM(n = 3) |
|---|---|---|---|---|---|
Female | 45 (66.2) | 236 (68.2) | 57 (69.5) | 25 (78.1) | 1 (33.3) |
Age of onset | 41.57 ± 15.46 | 44.32 ± 15.61 | 50.06 ± 12.12 | 42.75 ± 15.30 | 55 ± 11.13 |
Duration (months) | 21.94 ± 25.94 | 23.60 ± 49.18 | 23.50 ± 42.35 | 22.08 ± 35.86 | 70 ± 45.03 |
Fever | 5 (7.4) | 87 (25.1) | 36 (43.9) | 6 (18.8) | 0 |
Loss of weight | 19 (27.9) | 94 (27.2) | 19 (23.2) | 8 (25.0) | 0 |
Muscle weakness | 62 (91.2) | 253 (73.1) | 54 (65.9) | 22 (68.8) | 3 (100) |
Severe muscle weakness | 30 (44.1) | 59 (17.1) | 4 (4.9) | 3 (9.4) | 1 (33.3) |
Dysphagia | 24 (35.3) | 94 (27.2) | 14 (17.1) | 6 (18.8) | 0 |
Muscular atrophy | 2 (2.9) | 1 (0.3) | 0 | 0 | 0 |
Myalgia | 22 (32.4) | 169 (48.8) | 34 (41.5) | 12 (37.5) | 0 |
Arthralgia | 6 (8.8) | 123 (35.5) | 40 (48.8) | 9 (28.1) | 0 |
Skin involvement | 15 (22.1) | 334 (96.5) | 52 (63.4) | 3 (9.4) | 1 (33.3) |
 Heliotrope rash | 6 (8.8) | 238 (68.8) | 21 (25.6) | 0 | 0 |
 Mechanics’ hands | 1 (1.5) | 125 (36.1) | 25 (30.5) | 0 | 0 |
 Gottron’s sign | 3 (4.4) | 214 (61.8) | 27 (32.9) | 0 | 0 |
 V sign | 6 (8.8) | 198 (57.2) | 16 (19.5) | 1 (3.1) | 1 (33.3) |
 Shawl sign | 5 (7.4) | 143 (41.3) | 14 (17.1) | 1 (3.1) | 0 |
Raynaud phenomenon | 1 (1.5) | 27 (7.8) | 9 (11.0) | 3 (9.4) | 0 |
Interstitial lung diseases | 22 (32.4) | 161 (46.5) | 63 (76.8) | 11 (34.4) | 0 |
Malignancies | 5 (7.4) | 29 (8.4) | 3 (3.7) | 0 | 0 |
Other connective tissue diseases | 5 (7.4) | 39 (11.3) | 16 (19.5) | 10 (31.3) | 0 |
ALT (0-40 U/L) | 117 (64,241) | 38 (23,76) | 32 (24,87) | 43 (30,50) | – |
AST (0-40 U/L) | 85 (42,153) | 37 (22,76) | 32 (18,55) | 34 (21,75) | – |
LDH (100-250 IU/L) | 569 (347,836) | 264 (200,378) | 264 (209,398) | 291 (217,393) | – |
CK (26-200 IU/L) | 2289 (894,5505) | 103 (43,520) | 422 (54,1066) | 333 (35,1090) | – |
ANA (> 1:40) | 40/66 (60.6) | 198/323 (61.3) | 55/78 (70.5) | 19 (59.4) | 0 |
MSA | N = 68 | N = 334 | N = 82 | N = 26 | N = 3 |
 Anti-MDA5 | 0 | 70 (20.9) | 0 | 0 | 0 |
 Anti-NXP2 | 0 | 40 (12.0) | 0 | 0 | 0 |
 Anti-TIF1-γ | 0 | 57 (17.1) | 0 | 0 | 0 |
 Anti-Mi-2 | 0 | 26 (7.8) | 0 | 0 | 0 |
 Anti-SAE | 0 | 7 (2.1) | 0 | 0 | 0 |
 Anti-Jo-1 | 0 | 0 | 40 (48.8) | 0 | 0 |
 Anti-PL-7 | 0 | 0 | 22 (26.8) | 0 | 0 |
 Anti-PL-12 | 0 | 0 | 8 (9.8) | 0 | 0 |
 Anti-EJ | 0 | 0 | 12 (14.6) | 0 | 0 |
 Anti-SRP | 35 (51.5) | 0 | 0 | 0 | 0 |
 Anti-HMGCR | 13 (19.1) | 0 | 0 | 0 | 0 |
 MSA negative | 20 (29.4) | 134 (40.1) | 0 | 26 (100) | 0 |
MAA | |||||
 Anti-Ro-52 | 16 (24.2) | 64 (19.8) | 28 (35.9) | 4 (12.5) | 0 |
 Anti-Ku | 1 (1.5) | 0 | 4 (4.9) | 0 | 0 |
 Anti- PM/Scl | 1 (1.5) | 4 (1.2) | 1 (1.3) | 0 | 0 |
 Anti-AMA-M2 | 6 (9.2) | 11 (3.4) | 1 (1.3) | 3 (9.4) | 0 |