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Fig. 1 | BMC Musculoskeletal Disorders

Fig. 1

From: Clinical and pathological features of immune-mediated necrotising myopathies in a single-centre muscle biopsy cohort

Fig. 1

Pathological features of IMNM (A, D, G): A. scattered necrotic muscle fibres (white arrow); D. CD68+ macrophages expression on endomysia (black arrow); G. MAC deposition on sarcolemma of non-necrotic myofibres (black arrow) and sarcoplasm of necrotic muscle fibre (white arrow). Pathological features of LGMD 2B (B, E, H): B. muscle fibres of varying sizes (white arrow); E. CD68+ macrophages expression (black arrow); H. dysferlin expression deficient on sarcolemma. Pathological features of LGMD 2B (C, F, I): C. vacuolar muscle fibres (white arrow); F. non-overexpression of on MHC-I sarcolemma (black arrow); I. lipid droplet deposition in vacuolar muscle fibres (white arrow). A-C: HE staining; D-H: immunohistochemical staining; I. oil red O staining. IMNM, immune-mediated necrotising myopathy; LGMD, limb-girdle muscular dystrophy; LSM, lipid storage myopathy

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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