Table 3 Association between the FBN1 rs12916536 polymorphism with adolescent idiopathic scoliosis and its severity (N = 563)
FBN1 | Controls | All cases | OR ajustedb | Cobb < 45° | OR ajustedc | Cobb ≥ 45° | OR ajustedd | OR ajustede |
|---|---|---|---|---|---|---|---|---|
rs12916536 | (N = 378) | (N = 185) | (CI 95%) | (N = 74) | (CI 95%) | (N = 102) | (CI 95%) | (CI 95%) |
N (%) N (%) N (%) | ||||||||
GG | 123 (32.5) | 89 (48.1) | 1a | 37 (50.0) | 1a | 48 (47.1) | 1a | 1a |
GA | 207 (54.8) | 76 (41.1) | 0.52 (0.30–0.90) | 29 (39.2) | 0.54 (0.22–1.33) | 43 (42.1) | 0.68 (0.37–1.24) | 1.12 (0.55–2.26) |
AA | 48 (12.7) | 20 (10.8) | 0.95 (0.40–2.26) | 8 (10.8) | 2.40 (0.45–12.75) | 11 (10.8) | 0.91 (0.34–2.45) | 1.28 (0.42–3.90) |
GG | 123 (32.5) | 89 (48.1) | 1a | 37 (50.0) | 1a | 48 (47.1) | 1a | 1a |
GA + AA | 255 (67.5) | 96 (51.9) | 0.58 (0.35–0.98) | 37 (50.0) | 0.65 (0.28–1.55) | 54 (52.9) | 0.71 (0.40–1.27) | 1.15 (0.60–2.23) |
G | 453 (59.9) | 254 (68.6) | 1a | 103 (69.6) | 1a | 139 (68.1) | 1a | 1a |
A | 303 (40.1) | 116 (31.4) | 0.79 (0.54–1.16) | 45 (30.4) | 0.96 (0.51–1.81) | 65 (31.9) | 0.85 (0.56–1.30) | 1.14 (0.69–1.88) |