Table 2 Main biochemical & bone turnover outcomes by randomized group, mean (SD) unless stated otherwise
Clinical variable | Vitamin D3 (n = 68) | Vitamin D3 + Calcium (n = 68) | Calcium (n = 75) | Placebo (n = 66) | ||||
|---|---|---|---|---|---|---|---|---|
Baseline | 6 months | Baseline | 6 months | Baseline | 6 months | Baseline | 6 months | |
HbA1C (%) | 5.85 (0.9) | 5.82 (0.98) | 5.96 (0.99) | 5.75 (1.4) | 6.08 (1.1) | 5.86 (1.0) | 6.1 (1.3) | 6.02 (1.4) |
Hs CRP (mg/L) | 2.91 (2.8) | 3.48 (3.9) | 3.1 (3.5) | 3.3 (4) | 4.6 (6) | 4.03 (4) | 3.3 (3.3) | 3.06 (3.7) |
Calcium (mmol/L) | 2.29 (0.1) | 2.16 (0.2) | 2.29 (0.1) | 2.18 (0.2) | 2.25 (o.1) | 2.16 (0.2) | 2.28 (0.1) | 2.18 (0.2) |
PTH (pg/ml)* | 30 (17) | 29 (21) | 29 (11) | 22 (8) | 24 (12) | 22 (9) | 22 (13) | 24 (10) |
Osteocalcin (ng/ml) | 17 (6) | 22 (10) | 17.8 (6.5) | 19 (6.8) | 16 (10) | 19 (11) | 16 (7.4) | 19.6 (8) |
P1NP (ng/ml) | 50 (21) | 48 (25) | 50 (22) | 43 (19) | 45 (30) | 47 (27) | 46 (27) | 45 (21) |
CTX1 (ng/ml) | 10 (6) | 7.3 (4.7) | 10 (7.6) | 8.4 (6) | 10.5 (7) | 7.6 (5) | 12.5 (8) | 8.8 (6) |
U-DPD (nmol/L) | 102 (49) | 98 (46) | 91 (46) | 83 (41) | 79 (42) | 74 (41) | 100 (47) | 92 (49) |
U-PYD (nmol/L) | 217 (97) | 239 (126) | 247 (73) | 284 (116) | 196 (86) | 241 (126) | 242 (121) | 236 (115) |
PYD/CR | 20.8 (11) | 22 (11) | 24.7 (11) | 30.2 (12) | 24.9 (11) | 30 (18) | 23.7 (10) | 22.7 (8) |
DPD/CR | 9.2 (4) | 9.0 (4.4) | 9.5 (5.6) | 9.1 (4.4) | 10.7 (6.5) | 9.7 (6) | 10.1 (4.5) | 9.1 (4) |
Ca/Cr* | 0.201 (0.06) | 0.206 (0.06) | 0.208 (0.13) | 0.255 (0.09) | 0.313 (0.13) | 0.306 (0.014) | 0.204 (0.08) | 0.215 (0.09) |