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Fig. 4 | BMC Musculoskeletal Disorders

Fig. 4

From: Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway

Fig. 4

Knockdown of PAR-2 inhibited the activation of the ERK pathway in the spinal cord of the TCI rats. The L4-5 spinal cord tissues were obtained from the CIBP rats on the 14th day. A The co-immunoprecipitation of PAR-2 and ERK in spinal astrocytes was detected by immunoprecipitation assay; B The levels of the ERK pathway-related proteins were detected by WB. N = 6. The data were expressed as mean ± standard deviation. Independent t test was used for comparisons of data between 2 groups. *P < 0.05. t-CREB: total CREB; t-ERK: total ERK

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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