Fig. 1
CIBP model establishment in rats. The CIBP rat model was established using Walker 256 rat breast cancer cells. On the 3rd, 5th, 7th, 14th, and 21st d after TCI, A The changes of mechanical pain threshold were detected; B The changes of thermal hyperalgesia threshold were detected. The tibia of rats was collected 14 d after the TCI. C The morphological changes of the tibia were observed; D The changes of the tumor cell number in the tibial medullary cavity of rats were observed by HE staining. N = 6. The data were expressed as mean ± standard deviation. Independent t test was used for comparisons of data in panels A-B. *P < 0.05