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Fig. 3 | BMC Musculoskeletal Disorders

Fig. 3

From: Orai1 downregulation causes proliferation reduction and cell cycle arrest via inactivation of the Ras-NF-κB signaling pathway in osteoblasts

Fig. 3

Orai1 downregulation lowers the expression of cyclin D1 in MC3T3-E1 cells. a Western blotting was performed to assess the expression levels of cyclin D1, cyclin E, CDK4, and CDK6 in the MC3T3-E1 cells transfected with either control siRNA or Orai1 siRNA. b Real-time PCR was carried out to measure mRNA levels of cyclin D1, cyclin E, CDK4, and CDK6 in the MC3T3-E1 cells transfected with either control siRNA or Orai1 siRNA. Data are presented as means ± SD from three independent experiments. *p < 0.05 as compared with the control

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