Table 2 GO enrichment analysis of differentially expressed genes between rheumatoid arthritis and osteoarthritis
ID | GO term description | P | Genes |
|---|---|---|---|
Biological processes (BPs) | |||
GO:0,060,326 | chemotaxis, cell migration | 0.015 | CCL18/CXCL10/CXCL13 |
GO:0,001,906 | cytotoxicity, cell killing | 0.022 | GZMB/IL7R/RASGRP1/GZMH |
GO:0,002,544 | inflammatory response | 0.022 | CXCL13/TNFAIP3/CD247/CCL18/GCH1 |
GO:0,071,216 | response to stimulus | 0.014 | CXCL10/CXCL13/GCH1/TNFAIP3 |
GO:0,030,217 | T cell differentiation, cell mediated immunity | 0.023 | CD3D/IL7R/RASGRP1/CXCL13/TNFAIP3/GZMB |
Molecular functions (MFs) | |||
GO:0,008,009 | chemokine activity | < 0.001 | CCL18/CXCL10/CXCL13 |
GO:0,042,379 | chemokine receptor binding | 0.001 | CCL18/CXCL10/CXCL13 |
GO:0,045,236 | CXCR chemokine receptor binding | 0.001 | CXCL10/CXCL13 |
GO:0,048,020 | CCR chemokine receptor binding | 0.013 | CCL18/CXCL13 |
GO:0,005,125 | cytokine activity | 0.014 | CCL18/CXCL10/CXCL13 |
GO:0,001,664 | G protein-coupled receptor binding | 0.022 | CCL18/CXCL10/CXCL13 |
GO:0,005,126 | cytokine receptor binding | 0.022 | CCL18/CXCL10/CXCL13 |
Cellular component (CCs) | |||
GO:0,030,665 | clathrin-coated vesicle membrane | 0.036 | CD3D/IL7R |
GO:0,009,897 | external side of plasma membrane | 0.036 | CD3D/CXCL10/IL7R |
GO:0,042,101 | T cell receptor complex | 0.036 | CD247/CD3D |
GO:0,044,306 | neuron projection terminus | 0.036 | GCH1/SCRG1 |
GO:0,030,662 | coated vesicle membrane | 0.043 | CD3D/IL7R |
GO:0,030,136 | clathrin-coated vesicle | 0.043 | CD3D/IL7R |