Potential biomarkers that discriminate rheumatoid arthritis and osteoarthritis based on the analysis and validation of datasets

Table 1 Diagnostic specificity, sensitivity, and AUC values of 17 DEGs as determined by ROC analysis

Genes	Threshold ^a	Specificity, %	Sensitivity, %	AUC	AUC 95% CI
ADAMDEC1	7.1	97.8	100.0	0.999	0.996–1
RASGRP1	6.5	97.8	91.2	0.987	0.972–1
GZMB	6.7	93.4	94.7	0.982	0.964–1
CXCL13	7.5	91.3	91.2	0.946	0.903–0.989
GPR1	6.7	97.8	75.4	0.939	0.898–0.980
IL7R	8.4	87.0	87.7	0.918	0.863–0.971
CCL18	10.8	87.0	86.0	0.903	0.845–0.961
CD247	7.7	84.8	87.7	0.895	0.830–0.961
GCH1	8.6	95.0	71.9	0.895	0.840–0.954
QPCT	7.2	91.3	84.2	0.895	0.831–0.959
GZMH	8.3	87.0	84.2	0.889	0.812–0.966
ZIC1	10.6	87.0	94.7	0.877	0.794–0.960
CXCL10	9.4	91.3	75.4	0.869	0.798–0.940
SCRG1	8.9	87.0	79.0	0.858	0.776–0.939
CD3D	9.2	91.3	75.4	0.857	0.782–0.933
TNFAIP3	9.3	89.1	86.0	0.832	0.743–0.920
SEL1L3	9.2	87.0	75.4	0.812	0.720–0.901

AUC area under the curve, CI confidence interval, ADAMDEC1 ADAM Like Decysin 1, CD247 T-Cell Surface Glycoprotein CD3 Zeta Chain, CD3D T‑cell surface glycoprotein CD3 δ chain, CXCL10 C-X-C Motif Chemokine Ligand 10, CXCL13 C-X-C Motif Chemokine Ligand 13, GCH1 GTP Cyclohydrolase 1, GPR1 G Protein-Coupled Receptor 1, GZMB Granzyme B, GZMH Granzyme B, IL7R interleukin 7 receptor, QPCT Glutaminyl-Peptide Cyclotransferase, RASGRP1 RAS Guanyl Releasing Protein 1, SCRG1 Stimulator Of Chondrogenesis 1, SEL1L3 SEL1L Family Member 3, TNFAIP3 TNF Alpha Induced Protein 3, ZIC1 Zic Family Member 1
^afold changes in RA compared with OA tissue

ISSN: 1471-2474