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Table 3 Results and comparison of micro-CT microstructure indexes of femur between the two groups

From: Early effects of ovariectomy on bone microstructure, bone turnover markers and mechanical properties in rats

 

Time

OVX Group (n = 4)

Control Group (n = 4)

P

BV/TV (%)

1 week

0.12 ± 0.03

0.12 ± 0.05

0.738

4 weeks

0.07 ± 0.02

0.16 ± 0.04

0.001

8 weeks

0.06 ± 0.01

0.18 ± 0.03

<0.001

12 weeks

0.05 ± 0.01

0.13 ± 0.05

0.001

16 weeks

0.05 ± 0.01

0.13 ± 0.01

0.006

P

0.002

0.206

 

Conn. D (1/mm3)

1 week

49.36 ± 16.36

47.14 ± 24.78

0.842

4 weeks

25.17 ± 8.45

76.88 ± 21.43

<0.001

8 weeks

23.13 ± 7.29

63.82 ± 2.21

0.001

12 weeks

14.29 ± 6.86

51.47 ± 29.70

0.002

16 weeks

14.04 ± 1.88

48.01 ± 4.16

0.004

P

0.001

0.216

 

Tb.N (1/mm)

1 week

2.74 ± 0.39

2.36 ± 0.43

0.176

4 weeks

1.28 ± 0.19

3.29 ± 0.51

<0.001

8 weeks

0.82 ± 0.21

3.09 ± 0.21

<0.001

12 weeks

0.96 ± 0.24

2.56 ± 0.78

<0.001

16 weeks

1.09 ± 0.17

2.59 ± 0.22

<0.001

P

<0.001

0.074

 

Tb.Th (mm)

1 week

0.06 ± 0.00

0.07 ± 0.00

0.899

4 weeks

0.06 ± 0.01

0.06 ± 0.00

0.083

8 weeks

0.07 ± 0.00

0.07 ± 0.00

0.564

12 weeks

0.07 ± 0.00

0.07 ± 0.00

0.831

16 weeks

0.07 ± 0.00

0.06 ± 0.00

0.528

P

0.313

0.312

 

Tb.Sp (mm)

1 week

0.36 ± 0.06

0.44 ± 0.09

0.492

4 weeks

0.81 ± 0.12

0.30 ± 0.05

<0.001

8 weeks

1.31 ± 0.34

0.32 ± 0.03

<0.001

12 weeks

1.10 ± 0.25

0.41 ± 0.12

<0.001

16 weeks

0.97 ± 0.16

0.39 ± 0.03

<0.001

P

<0.001

0.100

 
  1. Data are presented as mean ± SD
  2. BV/TV The bone volume/total volume, Conn.D Bone trabecular connection density, Tb.N Trabecular bone number, Tb.Th Trabecular bone thickness, Tb.Sp Trabecular bone separation