Table 3 Univariate Associations with 6-Month outcomes (p-values)

Demographic Factors (97.1% complete data)

 Age

65.1 ± 8.2

0.29

0.14

0.06

0.30

 Sex

40.5% men

0.44

0.39

0.30

0.67

 Race

88% white

0.41

0.16

0.54

0.12

 Marital Status

70.8% married

0.47

0.54

0.83

0.68

 Education

62.4% bachelor’s

0.07

0.15

0.001

0.001

 Employment

47.1% working

0.79

0.78

0.70

0.90

Clinical Factors (96.8% complete data)

 BMI

31.1 ± 6.3

0.17

0.50

0.31

0.04

 Presence of other (non-OA) chronic pain

23.7%

0.001

0.003

0.82

0.38

 Number of painful body areas

2.6 ± 2.8

0.001

0.003

0.007

0.03

 Patient-reported neuropathic pain

6.5%

0.08

0.04

0.81

0.83

 Prior knee surgery

47.9%

0.87

0.30

0.44

0.66

 Number of drinks per week

3.8 ± 4.9

0.56

0.27

0.30

0.08

 Number of cigarettes per day

7.1 ± 12.5

0.81

0.13

0.27

0.30

 Use of NSAIDS

51.1%

0.54

0.19

0.75

0.10

 Use of acetaminophen

31.4%

0.80

0.71

0.18

0.78

 Use of opioids

9.5%

0.02

0.03

0.01

0.009

 Use of antidepressants

15.8%

0.71

0.43

0.15

0.37

Surgical Factors (93.1% complete data)

 Days in Hospital

2.7 ± 1.8

0.85

0.97

0.88

0.91

 Surgical Duration (minutes)

107 ± 54

0.55

0.79

0.66

0.51

 Type of Anesthesia

37.9% general

0.39

0.47

0.27

0.32

 Femoral Nerve or  Adductor Canal Block

35.1% yes

0.35

0.28

0.34

0.69

Health and Function (96.4% complete questionnaire data, 76.2% complete function testing data)

 SF-36 General Health

70.5 ± 17.1

0.99

0.23

0.003

0.009

 EuroQOL

75.9 ± 16.6

0.10

0.05

0.02

0.05

 Godin Exercise Questionnaire

26.8 ± 30.8

0.19

0.29

0.50

0.07

 6-Minute walk distance (feet)

937.6 ± 291.7

0.38

0.13

0.12

0.03

 Maximum pain during walking

41.6 ± 27.1

0.004

0.04

0.002

0.004

 Stair-climbing time (seconds)

20.6 ± 9.4

0.85

0.58

0.86

0.51

 Pain during stair climb

33.8 ± 25.3

0.03

0.28

0.001

0.004

Psychosocial Factors (94.8% complete data)

 PROMIS Anxiety (T-Score)

52.4 ± 5.3

0.004

0.03

0.003

0.001

 PROMIS Depression (T-Score)

50.1 ± 5.4

0.004

0.001

0.008

0.002

 PCS (0–52)

13.3 ± 11.4

0.0001

0.004

0.0004

 < 0.0001

 SPCS walking (0–24)

3.0 ± 4.3

0.06

0.10

0.23

0.37

 SPCS stair climbing (0–24)

2.5 ± 4.2

0.34

0.58

0.05

0.28

 ESSI

26.2 ± 5.8

0.002

0.0007

0.002

0.002

 Expectation for improvement (0–100)

88.0 ± 17.0

0.64

0.73

0.31

0.79

 PANAS Positive affect

36.2 ± 7.3

0.18

0.13

0.88

0.81

 BSI Somatization

1.7 ± 2.1

0.40

0.71

0.24

0.18

 NEO Agreeableness

36.1 ± 5.7

0.008

0.02

0.01

0.02

 NEO Extraversion

29.5 ± 6.8

0.02

0.02

0.02

0.04

 NEO Neuroticism

14.2 ± 7.2

0.01

0.05

0.007

0.74

 NEO Openness

27.9 ± 6.2

0.58

0.83

0.86

0.95

 NEO Conscientiousness

36.2 ± 6.4

0.67

0.61

0.80

0.006

Sleep-Related Factors (88.3% complete questionnaire data, 67.3% complete actigraphy data)

 PSQI

8.1 ± 4.2

0.006

0.008

0.0002

0.001

 ISI

9.6 ± 7.0

0.001

0.001

0.0002

0.002

 Fatigue Severity Scale

30.5 ± 16.0

0.0004

 < 0.0001

0.0003

 < 0.0001

 Sleep Efficiency (Actigraphy)

80.2% ± 9.5

0.09

0.35

0.34

0.12

 WASO in minutes (Actigraphy)

54.5 ± 27.4

0.09

0.09

0.03

0.06

 Total Sleep Time in minutes (Actigraphy)

389.9 ± 72.3

0.87

0.81

0.25

0.40

QST-Assessed Factors (86.3% complete data)

 Pain Sensitivity Questionnaire

4.9 ± 2.0

0.11

0.82

0.49

0.43

 PPTh Trapezius (kPa)

411.1 ± 201.5

65

0.87

0.45

0.52

 PPTh Patella (kPa)

532.9 ± 206.5

0.66

0.77

0.44

0.32

 Cuff Algometry Pain Threshold (mmHg)

142.7 ± 51.7

0.04

0.19

0.07

0.06

 Cold Pain Tolerance (sec)

75.0 ± 64.3

0.92

0.88

0.84

0.78

 Cold Pain Aftersensations

20.3 ± 21.4

0.51

0.10

0.09

0.07

 Conditioned Pain Modulation

123.8 ± 34.7

0.37

0.96

0.39

0.44

 Temporal Summation (Patella)

13.2 ± 17.6

0.02

0.20

0.03

0.03

 Temporal Summation (Finger)

10.8 ± 10.2

0.24

0.43

0.67

0.22