Skip to main content

Table 5 Performance of serological tests for diagnosing PJI

From: Serum D-lactate, a novel serological biomarker, is promising for the diagnosis of periprosthetic joint infection

 

AUC

(95% CI)

Youden index

(95% CI)

Optimal Cut-off

(95%CI)

Sensitivity

(%)

Specificity

(%)

PPV

(%)

NPV

(%)

PT (s)

0.69

(0.54 - 0.81)

0.38

(0.19 - 0.58)

12.10

(11.70 - 12.80)

46.15

92.31

85.71

63.16

INR

0.68

(0.54 - 0.81)

0.35

(0.15 - 0.50)

1.06

(0.99 - 1.07)

38.46

96.15

90.91

60.98

APTT (s)

0.71

(0.57 - 0.83)

0.42

(0.19 - 0.62)

32.20

(31.00 - 36.20)

69.23

73.08

72.00

70.37

FDP (ug/ml)

0.69

(0.54 - 0.81)

0.40

(0.160 - 0.60)

2.46

(1.92 - 7.79)

76.00

64.00

67.86

70.83

D-dimer (ng/ml)

0.67

(0.53 - 0.80)

0.36

(0.16 - 0.56)

265.00

(94.00 - 2342.14)

76.00

60.00

65.52

69.57

FIB (g/L)

0.80

(0.66 - 0.90)

0.54

(0.30 - 0.70)

3.27

(3.12 - 4.31)

80.77

73.08

75.00

79.17

ESR (mm/h)

0.80

(0.67 - 0.90)

0.50

(0.19 - 0.65)

32.00

(20.00 – 48.00)

73.08

76.92

76.00

74.07

Serum D-lactate (mmol/L)

0.80

(0.66 - 0.90)

0.62

(0.38 - 0.77)

1.14

(0.69 - 1.51)

88.46

73.08

76.70

86.40

  1. PJI Periprosthetic joint infection, AUC Area under the curve, CI Confidence interval, PT Prothrombin time, INR International normalized ratio, APTT Activated partial thromboplastin time, FDP Fibrinogen degradation products, FIB Fibrinogen, ESR Erythrocyte sedimentation rate, PPV Positive predictive value, NPV Negative predictive value