Bidirectional association between knee osteoarthritis and depressive symptoms: evidence from a nationwide population-based cohort

Table 2 Incidence and Hazard Ratios for Depressive Symptoms in Association with Knee Osteoarthritis, Overall and Stratified by Age and Sex (N = 2582)

	With KOA at baseline		Without KOA at baseline		Adjusted HR* (95% CI)	P
	Event/at risk (n / person-months)	Incidence rate per 1000 person-months	Event/at risk (n / person-months)	Incidence rate per 1000 person-months	Adjusted HR* (95% CI)	P
Overall	90 / 5814	15.48	666 / 86,164	7.73	1.38 (1.07–1.78)	< 0.001
Age < 65	64 / 4155	15.40	481 / 63,737	7.55	1.53 (1.13–2.07)	0.007
Male	23 / 2075	11.08	218 / 36,283	6.01	1.5 (0.91–2.46)	0.11
Female	41 / 2080	19.71	263 / 27,454	9.58	1.63 (1.10–2.42)	0.015
Age ≥ 65	26 / 1659	15.67	185 / 22,427	8.25	1.29 (0.81–2.06)	0.29
Male	13 / 939	13.84	101 / 14,641	6.90	1.3 (0.65–2.58)	0.46
Female	13 / 720	18.06	84 / 7786	10.79	1.1 (0.54–2.22)	0.79

The P-value for KOA-sex interaction was 0.993. The P-value for KOA-age interaction was 0.474.

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