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Table 5 Multiple linear regression for the assessment of OA risk factors on the levels of the three serum biomarkers

From: Associations between serum biomarkers of cartilage metabolism and serum hyaluronic acid, with risk factors, pain categories, and disease severity in knee osteoarthritis: a pilot study

Variable

sCOMPa

sHAb

sPIICPc

Est

SE

t

p-value

Est

SE

t

p-value

Est

SE

t

p-value

(Constant)

−14.73

103.4

0.143

0.8868

35.95

42.51

0.8458

0.3987

695.4

136.2

5.106

< 0.0001

Age (per year)

2.865

1.421

2.017

0.0450

1.773

0.584

3.035

0.0027

−0.622

1.872

0.3323

0.7400

BMI (per 1 kg/m2)

4.191

2.502

1.675

0.0955

− 1.663

1.029

1.616

0.1077

1.228

3.297

0.3725

0.7099

Gender

−30.76

26.32

1.168

0.2440

−4.817

10.83

0.445

0.6569

−62.96

34.69

1.815

0.0710

KL grade

15.08

14.36

1.050

0.2950

2.124

5.907

0.359

0.7195

− 163.5

18.92

8.639

< 0.0001

Resting VAS

0.843

6.409

0.132

0.8955

−2.250

2.636

0.8535

0.3944

0.321

8.445

0.0381

0.9697

Walking VAS

−7.532

5.840

1.290

0.1986

−0.615

2.402

0.2561

0.7981

2.459

7.695

0.3195

0.7496

Previous knee

Injury

20.49

24.21

0.846

0.3984

5.480

9.956

0.5504

0.5826

6.553

31.90

0.2054

0.8374

Occupational

Risk

78.31

25.64

3.054

0.0026

21.30

10.54

2.020

0.0447

26.83

33.78

0.7941

0.4281

Familial OA

1.902

22.94

0.083

0.9340

−2.966

9.436

0.3144

0.7536

−10.28

30.23

0.3402

0.7341

  1. p-values < 0.05 are consider significant and indicated in bold
  2. a R2 = 0.153, model ANOVA: F = 4.05, p < 0.0001
  3. b R2 = 0.112, model ANOVA: F = 2.84, p < 0.001
  4. cR2 = 0.560, model ANOVA: F = 26.81, p < 0.0001