Table 1 Characterization of COL1A1 and COL1A2 polymorphisms and probes for genotyping by TaqMan real-time PCR
Gene | Identified SNP | Position | Location | TaqMan Assays | Probe [SNP] |
|---|---|---|---|---|---|
COL1A1 | rs1107946 | −1997 G > T | PR | C___7477171_10 | CCTACTGTGGGTCAGTTCCAAGAGA [A/C] CCCCTCCCTAATAGGCGACAGGGGT |
COL1A2 | rs412777 | 19,276,090 A > C | Exon 25 | C___2545507_10 | ACGGCAGGCCTGGCCCAATTGGCCC [A/C] GCTGGAGCAAGAGGAGAGCCTGGCA |
COL1A2 | rs42524 | 19,277,392 G > C | Exon 28 | C___2258177_20 | AGGTGGAAAAGGTGAACAGGGTCCC [C/G] CTGGTCCTCCAGGCTTCCAGGTAAG |
COL1A2 | rs2621215 | 19,290,197 T > G | Intron 46 | C__16038824_10 | GTGAGGATTAAGGGAGATAGAAATA[G/T] ACATACAATAAAATCTCCTGGTAAC |