Fig. 4

RvD1 regulates OA-FLSs cell cycle progression. A The cell cycle of OA-FLSs incubated with RvD1 (0, 20, and 200 nM) for 48 h was detected using PI staining followed by flow cytometry. B Cyclin D1, cyclin B1, PCNA, and p53 were measured by western blot analysis in non-OA FLSs and OA-FLSs after incubation with RvD1 (0, 20, and 200 nM) for 48 h. *P < 0.05 as comparison with OA-FLS group. All experiments were repeated three times independently