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Table 4 Adverse events experienced by the duloxetine treatment group

From: Duloxetine in OsteoArthritis (DOA) study: effects of duloxetine on pain and function in end-stage hip and knee OA – a pragmatic enriched randomized controlled trial

 

Duloxetine intervention N = 57 – n (%)*

Experienced an AE

54 (94.7%)

Discontinued due to AE(s)

12 (21.1%)

Number of AEs per patient, median (Q1;Q3)

3 (2;5)

AEs in ≥5% of patients

 Headache

19 (33.3%)

 Somnolence

17 (29.8%)

 Nausea

16 (28.1%)

 Dry mouth

16 (28.1%)

 Constipation

12 (21.1%)

 Fatigue

10 (17.5%)

 Dizziness

10 (17.5%)

 Insomnia

7 (12.3%)

 Hyperhidrosis

6 (10.5%)

 Paresthesia

6 (10.5%)

 Diarrhea

4 (7.0%)

 Dyspepsia

4 (7.0%)

 Dysuria

4 (7.0%)

 Hot flushes

4 (7.0%)

 Vomiting

4 (7.0%)

 Palpations

3 (5.3%)

 Blurred vision

3 (5.3%)

 Musculoskeletal pain

3 (5.3%)

  1. *Unless stated otherwise. Other reported AEs: 3.5% (n = 2) of patients experienced abnormal dreams, dysgeusia, abdominal pain flatulence, abnormal orgasm, erectile dysfunction, abnormal urine odor, polyuria, muscle spasm and nocturia. 1.8% (n = 1) of patients experienced apathy, rigors, night sweats, tinnitus, tension, orthostatic hypotension, decreased libido, mood swings, cough, decreased appetite and elevated blood pressure