Table 2 Estimated means from models at T2 and T3

  Pain

0–100

45.3 (41.4, 49.2)

34.0 (30.1, 37.9)

11.3 (5.8, 16.8)

< 0.001

  Symptoms

0–100

49.1 (44.7, 53.5)

39.9 (35.5, 44.3)

9.2 (3.0, 15.4)

0.004

  ADL

0–100

47.8 (43.5, 52.1)

37.3 (33.0, 41.6)

10.5 (4.5, 16.6)

0.001

  QOL

0–100

26.8 (22.8, 30.8)

22.3 (18.3, 26.4)

4.5 (0.5, 12.3)

0.124

 mPDQ

−1-38

11.7 (10.3, 13.2)

15.4 (13.9, 16.8)

3.6 (1.6, 5.7)

0.001

  VAS-Rest

0–100

40.8 (34.8, 46.8)

57.8 (51.8, 63.8)

17.0 (8.5, 25.5)

< 0.001

  VAS-Movement

0–100

53.9 (48.9, 59.1)

70.6 (65.6, 75.7)

16.7 (9.5, 23.9)

< 0.001

 PGI-I^a

1–7

3.3 ± 1.7

5.0 ± 0.9

1.77 (1.2, 2.3)

< 0.001

  Much or very much better#

43.8% (21/48)

0% (0/51)

–

< 0.001

  Much or very much worse#

12.5% (6/48)

33.3% (17/51)

–

0.018

  Pain

0–100

43.1 (39.2, 47.0)

36.4 (32.6, 40.3)

6.7 (1.2, 12.1)

0.017

  Symptoms

0–100

44.8 (40.5, 49.2)

41.7 (37.4, 46.1)

3.1 (−2.8, 10.5)

0.325

  ADL

0–100

45.5 (41.2, 49.7)

40.2 (36.0, 44.5)

5.2 (−0.8, 11.2)

0.089

  QOL

0–100

27.0 (23.0, 31.0)

22.3 (18.3, 26.4)

4.7 (−1.0, 10.4)

0.105

 mPDQ

−1-38

13.0 (11.6, 14.4)

15.1 (13.7, 16.6)

2.1 (0.1, 4.2)

0.04

  VAS-Rest

0–100

42.6 (36.6, 48.6)

60.3 (54.3, 66.3)

17.7 (9.3, 26.2)

< 0.001

  VAS-Movement

0–100

58.8 (53.8, 63.8)

69.2 (64.2, 74.3)

10.4 (3.3, 17.6)

0.004

 PGI-I^a

1–7

4.0 ± 1.6

5.2 ± 1.1

1.2 (0.7, 1.7)

< 0.001

  Much or very much better#

.

22.5% (11/49)

0% (0/51)

–

< 0.001

  Much or very much worse#

22.5% (11/49)

51.0% (26/51)

–

0.004