Fig. 1
The radiological and histological findings of the primary osteosarcoma in the right tibia. Anteroposterior and lateral radiograph showed (A) an ill-defined osteolytic lesion with osteoid matrix involving the proximal metaphysis of the right tibia. Coronal fat-saturated T2-weighted MRI image (B) demonstrated an intramedullary lesion of heterogeneously high signal intensity with cortical breaching and soft tissue extension. Bone scintigraphy (C) presented diffusely increased activity in the right proximal tibia. (D) Pathological examination of the biopsy specimen revealed severe cytological atypia and regions of the eosinophilic chondroid matrix with chondroblastoma-like neoplastic cells (1) and neoplastic bone production (2)