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Table 2 Analysis of association of the eight SNPs gene polymorphism with the risk of KBD

From: Polymorphism of MMP-3 gene and imbalance expression of MMP-3 / TIMP-1 in articular cartilage are associated with an endemic osteochondropathy, Kashin- Beck disease

SNPs

Genotype (%) a

Dominant

Recessive

Log-additive

KBD (N = 274)

Controls (N = 248)

P

OR (95% CI)

OR (95% CI)

OR (95% CI)

rs650108

36.9/43.1/20.1

35.9/48.0/16.1

0.39

0.97 (0.68–1.34)

1.29 (0.82–2.01)

1.06 (0.84–1.35)

rs520540

48.2/36.9/15.0

48.0/43.1/8.9

0.07

1.00 (0.71–1.41)

1.91 (1.09–3.33) b

1.15 (0.89–1.48)

rs591058

48.2/36.9/15.0

48.0/44.0/8.1

0.03 b

1.02 (0.72–1.43)

1.98 (1.14–3.45) b

1.17 (0.91–1.51)

rs679620

447.4/37.1/15.4

48.0/45.2/6.9

0.02 b

1.00 (0.71–1.42)

2.31 (1.29–4.14) c

1.16 (0.90–1.50)

rs602128

48.2/36.9/15.0

49.2/41.9/8.9

0.08

1.04 (0.74–1.47)

1.81 (1.04–3.13) b

1.16 (0.90–1.50)

rs639752

48.2/36.9/15.0

48.0/45.2/6.9

0.007 b

1.01 (0.71–1.42)

1.97 (1.13–3.44) b

1.16 (0.91–1.54)

rs678815

48.2/36.9/15.0

48.0/43.1/8.9

0.07

1.02 (0.72–1.44)

1.91 (1.09–3.33) b

1.16 (0.90–1.49)

rs646910

82.8/16.1/1.1

82.3/16.9/0.8

0.91

0.86 (0.55–1.36)

0.45 (0.04–4.99)

0.85 (0.55–1.31)

  1. aHomozygote of the major allele/ heterozygote /homozygote of the minor allele
  2. bThe significance did not remain after correction for multiple testing
  3. cThe significance remained after correction for multiple testing