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Fig. 4 | BMC Musculoskeletal Disorders

Fig. 4

From: HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

Fig. 4

Runx-2 (a) and MMP-13 (b) IHC staining was increased in rats that underwent ACLT and treated with Ad-GFP, but it was lower in the Ad-m-HDAC4, Ad-HDAC4 and sham-operated groups. The staining of Runx-2 and MMP-13 was lower in the Ad-m-HDAC4 treated rats than in the Ad-HDAC4 treated rats. In contrast, Col 2a1 expression was higher in the Ad-m-HDAC4 and Ad-HDAC4 and sham-operated groups than in the Ad-GFP treated group. Compared to Ad-HDAC4 treated rats, Col 2a1 staining was greater in the Ad-m-HDAC4 treated rats (c)

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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