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Fig. 1 | BMC Musculoskeletal Disorders

Fig. 1

From: HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

Fig. 1

HDAC4 and m-HDAC4 inhibit chondrocyte hypertrophy in vitro OA model. a The green fluorescence of m-HDAC4-GFP was located in the nuclei of chondrocytes, while HDAC4-GFP was located in the cytoplasm of cells after infection with adenoviral vectors (MOI:200). Scale bars: 100 μm. b RT-qPCR showed that upregulation of m-HDAC4 decreased the mRNA expression of Runx-2, MMP-13, and Col 10a1 and increased the mRNA expression of Col 2a1 and ACAN in rat chondrocytes more effectively than HDAC4.* indicates P < 0.05

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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