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Fig. 1 | BMC Musculoskeletal Disorders

Fig. 1

From: Osteoclasts secrete leukemia inhibitory factor to promote abnormal bone remodeling of subchondral bone in osteoarthritis

Fig. 1

(A) Safranin-O fast green staining shows progressive proteoglycan loss and the cartilage damage at 4 and 8 weeks postoperatively. Scale bar, 200 μm. (B, C) Histologic OA score of the articular cartilage at 4 and 8 weeks. (D, E) Immunostaining and quantitative analysis for TRAP in sagittal sections of the subchondral bone medial compartment at 4 weeks after ACLT surgery. Scale bar, 50 μm. Vehicle = ACLT surgery treated with vehicle. ALN = ACLT surgery treated with alendronate. Numerical data are presented as means ± SD; **p < 0.01 compared to the sham group, ##p < 0.01 compared to the vehicle group

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